33) Upon binding to EC-displayed selectins, the CLA-expressing T cells extravasate
from dermal venules.
In every state of things, it is necessary that the one and the other be in a proportion of force and extension; if the tissue expands as the volume of the substance augments, the progress of the social body takes place without violent upheaval; but if, instead of an elastic strength, it offers a brittle rigidity, the moment will come when all proportion will cease, and it will be necessary that the humour be consumed, [or it will rupture] its envelope and extravasate
It is believed that toxic materials, including pancreatic enzymes, and other toxic substances are released by the pancreas and extravasate
into the retroperitoneal spaces, lesser sac, and the peritoneal cavity.
The data suggest that selectin expression plays a key role in blood cancer cell homing to bone marrow, and that GlycoMimetics' lead drug candidate - pan-selectin inhibitor GMI-1070 - reduces the rate at which multiple myeloma cells extravasate
from the bloodstream, thereby inhibiting homing to the bone marrow.
These cells might then intravasate into the blood or lymphatic circulation and subsequently extravasate
from the circulation and establish a secondary tumor in another organ far from the primary tumor.
16) Interestingly, the investigators had four patients for whom fluid did not extravasate
from the arthrotomy (false negative rate = 7%; 4/60); however, these patients were excluded from the study analysis.
Metastasis is a sequential process in which tumor cells detach from the primary growth, invade through the surrounding host tissue into the circulation and subsequently disseminate to distant organs, where they arrest, extravasate
and proliferate to form metastatic foci (Poste and Fidler 1980).
If appropriately stimulated while rolling, leukocytes will bind firmly to the endothelium via integrins and subsequently extravasate
Once macromolecules extravasate
from the circulation or blood vessels into the tumor interstitium, they remain in the tumor for a long time without being cleared.