Multiplex PCR for detection of genes for Staphylococcus aureus enterotoxins, exfoliative
toxins, toxic shock syndrome toxin 1, and methicillin resistance.
A 41-year-old woman who had been treated with celecoxib had an exfoliative
dermatitis diagnosed as toxic epidermal necrolysis.
The etiology of the patient's exfoliative
erythroderma remains unclear, with psoriasis or atopic dermatitis as the most likely cause.
1) SEA 0 SEB 32 (100) SEC 0 SED 0 SEE 0 SEG/SEI 0 SEH 0 * PVL, Panton-Valentine leukocidin; ETA, exfoliative
toxin A; ETB, exfoliative
toxin B; TSST-1, toxic shock syndrome toxin-1; SEA, staphylococcal enterotoxin A; SEB, staphylococcal enterotoxin B; SEC, staphylococcal enterotoxin C; SED, staphylococcal enterotoxin D; SEE, staphylococcal enterotoxin E; SEG, staphylococcal enterotoxin G; SEI, staphylococcal enterotoxin I; SEH, staphylococcal enterotoxin H.
NSAIDs can cause serious skin adverse events such as exfoliative
dermatitis, Stevens - Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal.
The strain had an agr type 1 allele and the lukS-PV/lukF-PV genes encoding PVL (Figure), but harbored no toxin genes (sea through see, tsst, eta, and etb genes encoding staphylococcal enterotoxins A though E, toxic shock syndrome toxin, and exfoliative
toxins A and B, respectively).
anaphylaxis, angioedema or exfoliative
PCR was used to detect the exfoliative
toxin genes eta and etb as previously described (16).
These strains were sent to the French Reference Center for Staphylococci, where genetic sequences encoding accessory gene regulator (agr) subtypes, enterotoxins, exfoliative
toxins, toxic-shock syndrome toxin-1, hemolysins, and LukE-LukD leukotoxin were detected by polymerase chain reaction (PCR)-based methods.
Some strains produce additional exoproteins that may be responsible for particular clinical manifestations, including the staphylococcal enterotoxins, the toxic-shock syndrome toxin-1, the exfoliative
toxins, and the Panton-Valentine leukocidin (PVL) (3).
You should not use Taclonex([R]) Ointment or Taclonex Scalp([R]) Topical Suspension if you are allergic to any of their ingredients, have thin skin (atrophy) at the treatment site, have known or suspected calcium metabolism disorders (too much or too little calcium in your blood or urine), have erythrodermic, exfoliative
, or pustular psoriasis, or have severe kidney or severe liver disease.
There have been postmarketing reports of serious hypersensitivity reactions in patients treated with JANUVIA, such as anaphylaxis, angioedema, and exfoliative
skin conditions including Stevens-Johnson syndrome.
NSAIDs can cause serious dermatologic adverse reactions such as exfoliative
dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis, which can be fatal.
Solaraze should not be applied to open skin wounds, infections, or exfoliative
Patients have rarely developed serious exfoliative
cutaneous reactions, such as Stevens-Johnson syndrome, during treatment with VFEND.