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Secondary endpoints for the study comparing Ultibro Breezhaler to SFC included superiority in terms of rate of all COPD exacerbations over the study duration and efficacy in terms of the following: time to first COPD exacerbation (mild/moderate/severe); rate and time to first moderate-to-severe COPD exacerbation; lung function (trough FEV1); health-related quality of life (as measured by the shortened version of the St George's Respiratory Questionnaire SGRQ-C ); rescue medication use and safety.
The likelihood of being exacerbation free at 1 year was 74% for a long-acting beta-agonist (LABA) plus ICS, vs.
The risk of exacerbation was greatest in those with a body mass index over 30 kg/m2 (odds ratio, 2.
For high-risk patients, this higher dose of NAC at 600 mg twice daily significantly reduced the exacerbation frequency at 8 and 12 months, a prolonged amount of time until the first exacerbation and an increased probability of having no exacerbations at 1 year, compared with placebo.
Randomized trial results demonstrate roflumilast decreases exacerbations and hospitalizations in severe COPD patients with uncontrolled chronic bronchitis already receiving maximal dosage of inhaled dual or triple therapy -
We examined publications since 2000 relating indoor exposures and exacerbation of asthma in conjunction with prior evidence (IOM 2000) and provide conclusions about the current strength of evidence.
Of the 143 patients that completed the trial, the treatment group experienced significant reduction in the frequency of asthma exacerbation and frequency of catching a cold.
14-16) Hence, based on the exacerbation rates, two asthma phenotypes have been described.
So it was thought that giving them extra vitamin D might help prevent exacerbations in symptoms or trips to the hospital because of shortness of breath or mucus in the airways but that turned out not to be the case.
In the patients not receiving chronic inhaled antibiotics, the pulmonary exacerbation rate in the ataluren group was 43% lower than the rate in the placebo group.
The researchers studied 182 patients with severe COPD to determine whether supplementation with high doses of vitamin D could reduce the incidence of COPD exacerbations.
The nature of onset of an exacerbation "is the prodrome that is reported to the physician when the patient comes into the clinic, and dictates the courses of therapy," he noted at the conference.
There was no difference in clinical scores, FEV1, pulmonary exacerbation rates between two groups at baseline, 6 months and at 12 months.
When an asthma exacerbation presents, the patient must be equipped to (1) assess and monitor signs and symptoms, (2) implement patient care skills, (3) evaluate the role of allergens and irritants, and (4) self-adjust medications appropriately.
assemble 15 articles that discuss the acute exacerbation of chronic obstructive pulmonary disease (COPD).
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