Also, more recent literature has noted that BPA may be metabolized into other biologically active agents through oxidative cleavage to create the estrogenically
active metabolite 4-methyl-2,4-bis(4-hydroxyphenyl)pent-l-ene (MBP), which is reported to be 500 times more potent than BPA in vivo (Okuda et al.
The major metabolite of BPA, BPA-monoglucuronide, has no estrogenic activity, but oxidative cleavage of BPA to form the estrogenically
active metabolite 4-methyl-2,4-bis(4-hydroxyphenyl)pent-l-ene (MBP) has been observed in rat liver.
The distinction between conjugated and unconjugated BPA is an important one, especially in blood samples, where the presence of unconjugated BPA in circulation indicates internal exposure to the parent compound, which is estrogenically
Genistin is the naturally occurring isoflavone predominantly contained in soy formula, which can easily be hydrolyzed in the gut to the estrogenically
active form of the compound, genistein, based on reporting of high plasma (Setchell et al.
As is most often the case in science," he says, "there was a whole lot more that was unknown than was known about low-dose exposure to estrogenically