This was a case of erythroleukemia with >50% erythroid
Among the controls, the erythroid
lineage was generally normal in number although there were also some cases with hypoplasia or hyperplasia.
29] Testosterone could enhance the platelet count by stimulating the proliferation of erythroid
and myeloid progenitors as well.
Dysplastic changes were seen in myeloid (30%) and erythroid
cell lines (28%).
Of note was the concurrent moderate decrease in PCV (30%, down from previous measurement of 40%) indicating that the erythroid
cell line was also affected.
An abundant erythroid
protein that stabilizes free [alpha]-haemoglobin.
A soluble form of TfR (sTfR) detected in serum is closely related to erythroid
directly suppresses the proliferation of erythroid
Primary acquired sideroblastic anaemia, which involves abnormal haematopoiesis, is idiopathic, as it is not clear what the cause of defective haem synthesis is in the abnormal erythroid
clone (3) This type of sideroblastic anaemia is the one most commonly seen in the haematology laboratory, as it is part of the myelodysplastic syndromes--a series of clonal haematopoietic stem cell diseases.
The function of erythropoietin is to stimulate erythropoiesis in the bone marrow by stimulating committed stem cells to proliferate and differentiate, decreasing erythroid
precursor (normoblast) maturation time, increasing the rate of hemoglobin synthesis, and stimulating early release of bone marrow reticulocytes.
Bone marrow aspiration cytology revealed normal cellularity, with myeloid, erythroid
, and megakaryocyte cell lines present.
However, the erythroid
series showed no morphologic abnormalities and an MCV of 94.
Two compounds (butyl p-tolyl sulfide and 6-methyl-4-chromanone) induced erythroid
differentiation at concentrations higher that those able to give a 50% inhibition of K562 cell growth; one compound (5-methoxypsolaren) was able to induce K562 differentiation when used at concentrations lower than that causing 50% inhibition of K562 cell growth.
Blood cells originate from such stem cells, which subsequently differentiate into lymphoid, myeloid and erythroid
Cytokine-induced synthesis of hepcidin plays a crucial role in macrophage iron retention, which underlies the anemia of chronic disease by limiting the availability of iron for erythroid