He was hospitalized when he developed eruptive xanthoma
at the age of 9 years.
Sweet syndrome 9 GVHD 11 Mass-forming lesions Diffuse large B-cell lymphoma 2 Marginal zone B-cell lymphoma 1 Peripheral T-cell lymphoma 17 NK/T-cell lymphoma 17 Mycosis fungoides 11 Merkel cell carcinoma 10 Langerhans cell histiocytosis 3 Eruptive xanthoma
5 Inflammatory lesions Eosinophilic dermatitis 1 Mastocytosis 2 Lichenoid dermatitis 4 Bullous pemphigoid 2 Folliculitis 1 Abbreviations: GVHD, graft-versus-host disease; NK, natural killer.
and lipemia retinalis present when plasma triglycerides concentration > 2000 and 4000 mg/dl respectively.
They include acanthosis nigricans and NLD, both seen in this patient, as well as bullous diabeticorum, diabetic dermopathy, eruptive xanthomas
, generalized granuloma annulare, infections (yeast or bacterial), neuropathic foot ulcers, and scleredema.
Small, yellow-orange or red-brown plaques that "explode" over a few days or weeks and are located all over the body but concentrated on the elbows and knees are probably eruptive xanthomas
associated with extremely high triglyceride levels (into the thousands).