22 Patients with hypertriglyceridaemia may also develop eruptive xanthoma
Affected patients present with chylomicronemia, eruptive xanthomas
, lipemia retinalis, hepatosplenomegaly, and recurrent attacks of pancreatitis, which may ultimately lead to chronic pancreatic insufficiency.
Cutaneous manifestations of diabetes are classified into four categories: Skin lesions with strong-to-weak association to diabetes (necrobiosis lipoidica, diabetic dermopathy, diabetic bullae, yellow skin, eruptive xanthomas
, perforating disorders, acanthosis nigricans, oral leucoplakia, lichen planus), infections (bacterial, fungal), cutaneous manifestations of diabetic complications (microangiopathy, macroangiopathy, neuropathy) and skin reactions to diabetic treatment (Sulphonylureas or insulin).
in association with metabolic syndrome.
and lipemia retinalis present when plasma triglycerides concentration > 2000 and 4000 mg/dl respectively.
Small, yellow-orange or red-brown plaques that "explode" over a few days or weeks and are located all over the body but concentrated on the elbows and knees are probably eruptive xanthomas
associated with extremely high triglyceride levels (into the thousands).
Various common and rare skin disorders associated with diabetes include diabetic dermopathy, necrobiosis lipoidica, diabetic bullae, diabetic thick skin, yellow skin, acanthosis nigricans, eruptive xanthomas
, disseminated granuloma annulare, scleredema, yellow nails, skin tags, diabetic rubeosis, vitiligo and lichen planus.