The studies detected a previously unknown brain cancer mutation with potential as a new drug target, identified epithelial cancer
antigens that have shown promise as targets for immunotherapy, and detected breast cancer mutations that were used with an avatar model of the patient's cancer to guide personalized treatment.
They used miR-429, one of a family of microRNAs previously implicated in epithelial to mesencymal changes in other cancers, to see if it could turn the mesenchymal cancer cells back into epithelial cancer
The combination of biomarkers performed well in both pre- and post-menopausal women, accurately stratifying 95 percent of patients with epithelial cancer
as high risk and 75 percent of benign cases as low risk.
Under the influence of oncogenic factors such as inflammatory cytokines, polarized epithelial cancer
cells detach from their underlying basement membrane and progressively lose lineage-specific markers such as E-cadherin and acquire mesenchymal markers (e.
Gorodeski's presentation will cover the physiological and patho-biological roles of P2X7 in uterine epithelial cancer
development; the role of hyper-methylation of the P2X7 gene as it relates to P2X7 mRNA expression; the post-transcriptional enhancement of P2X7 expression by compounds that promote de-methylation; and the therapeutic and cancer prevention potential of treatments based upon up-regulation of P2X7-mediated apoptosis.
P2X7 from Bench to Bedside: Role of Apoptosis in Epithelial Cancer
Screening, Treatment and Prevention"
The addition of HE4 to monitor recurrence or progressive epithelial cancer
is an important advance in ovarian cancer care and will provide us with the best information available today.
Expression of EpCAM is variable across epithelial cancers
and, more importantly, clinically relevant subpopulations of CTCs may go through an epithelial-to-mesenchymal transition or exist as cancer stem cells (12).
Some epithelial cancers
are known to occur in transitional zones between two types of epithelium (layers of tissue that line the body and organs and form glands), while others originate in epithelial tissue stem cells.
There are different types of epithelial cells, and all can develop into different types of epithelial cancers
The age-specific incidence rates of epithelial cancers
arising in the pancreas, gallbladder, EHBD, and ampulla from 1973 through 2005 were calculated at 5-year intervals to age 85+ (Figure 2).
Catumaxomab has two different antigen binding sites: While one arm of the antibody recognizes and binds to T cells, the other arm binds EpCAM (epithelial cell adhesion molecule) that is overexpressed in many types of epithelial cancers
Of the 128 women with pelvic masses, 44 had malignant epithelial cancers
Research Triangle Park, NC), a worldwide leader in drug development based on basal lamina research, and DakoCytomation A/S (Glostrup, Denmark), a worldwide leader in cancer diagnostic testing, have signed an agreement according to which DakoCytomation is granted a license to develop and commercialize diagnostic applications of the monoclonal antibody, MetaStain, which has demonstrated the potential to identify invasive epithelial cancers
This characteristic may be responsible for lycopene's ability to mitigate epithelial cancers
, such as breast cancer and prostate cancer, and for its ability to mitigate coronary artery disease," explains Autar Mattoo, head of the U.