epistasis


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  • noun

Synonyms for epistasis

the suppression of a gene by the effect of an unrelated gene

References in periodicals archive ?
Epistasis that has been ignored in most genetic association studies might explain a large portion of genetic variation for complex traits.
Biological epistasis results from physical interactions among biomolecules (e.
Spontaneous autoimmune disease in Fc(gamma)RIIB-deficient mice results from strain-specific epistasis.
Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: evidence for epistasis between 1p and IBD1.
The epistasis effects were calculated from the deviation of the least square means of PRLR3*RBP4, PRLR3 and RBP4 from the population mean of the model.
In the presence of epistasis, the effects of alleles at one locus on an individual's phenotype depend upon the "genetic background" at other loci.
Cross-breeding studies have demonstrated that the presence of active mitochondria inherited from UChB females can fully abolish the reduction of alcohol consumption associated with the presence of less efficient ALDH2 variants--a phenomenon known as epistasis.
The usual assumptions of a classic twin study [no gene-environment interaction or correlation, no assortative mating or epistasis, and that the degree of environmental similarity is equal for MZ and DZ twins (the equal environment assumption)] were made.
Moreover, HG1, HG2, and HG3 appear to act independently on each growth trait, since we could detect no QTL when we performed analysis using the F2 epistasis module in GridQTL software (Hernandez-Sanchez et al.
Three hypotheses of nonadditive gene action may explain heterosis: overdominance (Shull 1908, East 1936), dominance (Bruce 1910) and epistasis (Stuber et al.
Areas of particular interest for this initiative include 1) implications and appropriate uses of different sampling strategies; 2) analytical tools to discover patterns of genotypic variation and their roles in conferring phenotype; 3) incorporation of data from new technologies; 4) development of robust methods that are c6mpatible with real data (missing or incomplete data, typing errors, experimental errors); and 5) development of mathematical models based on empirical information, which includes such biological realities as epistasis, recombination, mutation, protein structure, cell biology, metabolic pathways, development, population history, and evolution.
Validation failure may be due to a lack of true associations between the trait and marker but could also be caused by differences in SNP frequencies, different marker-causative mutation linkage phases, genotype-by-environment interactions or epistasis as well as sample size effects and the way the trait is measured.
dominance and epistasis [Falconer & Mackay 1996]) in outcrossed hybrids by comparing each of the 10 outbred strains to the mean of the two inbred strains from which it was created.
Areas of particular interest for this initiative include 1) implications and appropriate uses of different sampling strategies; 2) analytical tools to discover patterns of genotypic variation and their roles in conferring phenotype; 3) incorporation of data from new technologies; 4) development of robust methods that are compatible with real data (missing or incomplete data, typing errors, experimental errors); and 5) development of mathematical models based on empirical information, which includes such biological realities as epistasis, recombination, mutation, protein structure, cell biology, metabolic pathways, development, population history, and evolution.