The t(8; 9)(p22; p24); PCM1-JAK2 fusion causes an MPN that can resemble atypical CML, chronic eosinophilic leukemia
, or primary myelofibrosis.
Chen, "Chronic eosinophilic leukemia
, NOS with t(5;12)(q31;p13)/ ETV6-ACSL6 gene fusion: a novel variant of myeloid proliferative neoplasm with eosinophilia," Human Pathology: Case Reports, vol.
9]/L * BCR/ABL1 negative * 40-50% exhibit JAK2 mutation2 Chronic eosinophilic leukemia
, * Clonal proliferation of not otherwise specified (CEL/ eosinophil precursors NOS) * Eosinophil count greater than 1.
17) Eosinophilia may be observed in: (1) benign reactive eosinophilia, (2) eosinophilia of miscellaneous malignant disorders, and (3) sustained idiopathic eosinophilia, including idiopathic hypereosinophilic syndrome and eosinophilic leukemia
Chronic eosinophilic leukemia
(CEL), a rare entity, is classified by the WHO as 2 groups of patients with neoplastic eosinophils: those that have a myeloid or lymphoid neoplasm with eosinophilia, and abnormalities in PDGFRA, PDGFRB, or FGFR1 genes, and those integrated in a subchapter as MPN that have chronic eosinophilic leukemia
, not otherwise specified (1-3).
Other, less common disorders in this group include chronic neutrophilic leukemia (CNL), chronic eosinophilic leukemia
(CEL), mastocytosis, and myeloproliferative neoplasm, unclassifiable (MPN,U).
Chronic myelogenous leukemia Chronic myelomonocytic leukemia Mast cell leukemia Chronic monocytic leukemia Chronic neutrophilic leukemia Chronic eosinophilic leukemia
65) This disorder is variably known as chronic eosinophilic leukemia
or myeloproliferative HES, among other names, but is recognized in the 2008 WHO classification as myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, or FGFR1.
Patients with SM-MPN may present with prominent eosinophilia, and many of these patients may fulfill criteria for chronic eosinophilic leukemia
if a clonal molecular or cytogenetic abnormality or increased number of blasts (>5% in the bone marrow) is identified.