HIV entry inhibitors
in early development DRUG NAME CURRENTLY GIVEN COMPANY AMD-070 By mouth Anormed AMD-887 By mouth Anormed PRO-140 By injection or infusion * Progenics BMS-488043 By mouth Bristol-Myers Squibb UK 427,857 By mouth Pfizer SP-01A By mouth Samaritan Pharmaceuticals SCH-D By mouth Schering Plough TNX-355 By infusion Tanox GSK(GW)-873140 By mouth GlaxoSmithKline PRO-542 By injection or infusion * Progenics * infusion is when medication is given directly into a vein over a period of time.
Overall there were more than a dozen new agents, including integrase inhibitors and entry inhibitors
, discussed in various stages of research presented at this meeting.
The entry inhibitor
nearest to market is T-20 (enfuvirtide).
Currently, there are 4 groups of antiretroviral medications used to treat HIV/AIDS: 1) nucleoside/nucleotide reverse transcriptase inhibitors or "nukes," 2) non-nucleoside reverse transcriptase inhibitors or "non-nukes," 3) protease inhibitors, and 4) entry inhibitors
(see table below).
Other investigators working on entry inhibitors
have made new and exciting observations that may provide a glimpse into the future of entry inhibitors
In the area of virology, Progenics is developing the HIV entry inhibitor
PRO 140, a humanized monoclonal antibody targeting the entry co-receptor CCR5, which is currently in phase 2 clinical testing.
Viral entry inhibitors
represent a novel and interesting new class of antiviral agents," said John McHutchison, MD, Professor of Medicine at Duke University and Chairman of iTherX Scientific and Clinical Advisory Board.
In November, Progenics also announced the selection of a proprietary small-molecule drug candidate, designated PRO 206, a novel HCV entry inhibitor
for clinical development as a treatment of hepatitis C virus (HCV) infection.
Its products include protease inhibitors, levetiracetam assay, topiramate assay, non-nucleoside reverse transcriptase inhibitors, gabapentin assay, lamotrigine assay, zonisamide assay, methotrexate assay, thyroxine assay, and entry inhibitor
Our compound is the broadest and most potent entry inhibitor
described so far," said Michael Farzan, a TSRI professor who led the effort.
Scientists from Drexel's College of Engineering; School of Biomedical Engineering, Science and Health Systems; and College of Medicine have named the microbicide DAVEI - which stands for 'Dual Action Virolytic Entry Inhibitor
Once experience with these drugs develops, it is likely that various 'nuc'-sparing combinations that incorporate an entry inhibitor
will start to become popular.
HIV co-receptor tropism tests can help physicians identify which patients, of the estimated 500,000 people in the United States being treated for HIV infection, will benefit from entry inhibitor
drugs, the latest development in life-enhancing anti-retroviral therapies.
The response rate was even more impressive in the subgroup whose background medications included enfuvirtide, also known as T20, an anti-HIV entry inhibitor
AMEX:LIV), Las Vegas,a developer of innovative drugs, has announced that an in-vitro study conducted on its oral entry inhibitor
SP-10 by the National Institutes of Allergy and Infectious Diseases (NIAID), found SP-10 to have significant antiviral activity with Hepatitis C Virus (HCV) infection.