Being able to get engraftment
allows you to pick a smaller cord blood sample that might be a better match.
We are seeing what we believe to be dose-dependent marked increases in both absolute CD4 cell counts as well as the engraftment
of CCR5 modified T cells with the increasing doses of Cytoxan," he said at the Conference on Retroviruses and Opportunistic Infections 2014.
In running a second cohort of the Phase IB trial, which included 12 patients, dmPGE2 appeared to enhance the engraftment
properties of the blood stem cells in humans and was deemed safe to continue into Phase II.
Phenotypical analysis of blood leukocytes on day +55 showed normal CD56+/16+ natural killer cells and good T-cell engraftment
but no B cells.
Chimerism analysis using polymerase chain reaction (PCR)-based amplification of short tandem repeat (STR) markers has grown to be the most widely used tool for analyzing stem cell engraftment
over fluorescent/ns/fu hybridization (FISH) and other cytological methods.
Our patient was successfully transplanted using a conditioning regimen, which was not very highly immunosuppressive but enough to achieve engraftment
This study attempted to relate the immature reticulocytes fractions with bone marrow engraftment
or recovery in patients post bone marrow transplant.
Discussion: Pegfilgrastim as compared with filgrastim resulted in decreased cytokine cost and fewer injections with a comparable number of CD34+ cells mobilized and no significant difference in the number of apheresis collection procedures performed or time to engraftment
Histology confirmed that myoblast engraftment
and myofiber formation occurred, but further research is needed to assess whether the transplant procedure imparts any functional improvement, the researchers said.
The tumor initiating capacity of the cells was again verified in an in viva NOD/SCID engraftment
Primary endpoints are the incidence of acute graft-versus-host disease and the incidence of transplant engraftment
Barker doesn't know why one transplant wins out over the other, but the mere presence of the losing transplant seems to facilitate engraftment
of the winner, she says.
may have failed because Getty's immune system was not sufficiently suppressed before the transplant, he said.
Study data was announced today during an oral presentation titled Nicord[R] Expanded Hematopoietic Progenitor Cells (HPC) Are Capable of Outcompeting the Unmanipulated (UM) Cord Blood Unit and of Prolonged Myeloid and Lymphoid Engraftment
Following Myeloablative Dual Umbilical Cord Blood (UCB) Transplantation.
Adoptive Transfer of ZFN Mediated CCR5 Modified CD4 T-cells (SB-728-T) in HIV Subjects Leads to Long Term Engraftment
of HIV Resistant T Memory Stem Cells and Decrease in Size of Latent Reservoir -- Abstract #C-7 Session: Clinical Trials Spotlight Oral Presentation -- Thursday, May 14, 2015