and neurogenic inflammation in rats with respiratory infections.
Non-proteasome proteases have been divided into exopeptidases and endopeptidases
depending on the cleavage position of target proteins.
OXFORD, England, March 2, 2011 /PRNewswire/ -- Syntaxin, a biotechnology company developing novel biopharmaceuticals to control cell secretion, today announces its partner Allergan, Inc has initiated two Phase II trials to evaluate the safety and efficacy of its re-targeted endopeptidase
drug candidate AGN-214868.
dependent neutral endopeptidase
family that degrades ECM components and plays an essential role in SMC proliferation and migration (5, 6).
Other ways for a rise of tachykinins in these patients include the reduced effect of neutral endopeptidase
, an enzyme that is important in degrading and inactivating tachykinins.
11,12) Expression of the glycoprotein endopeptidase
CD10 is rare in IPMN and common in MCN (9); here, this marker was diffusely positive in an apical, membranous pattern.
in the nerve cells, has been utilized in a novel 'second generation' ELISA, the endopeptidase
6) Branched PEGs were linked to lysostaphin, an antibacterial endopeptidase
that can be used to fight multidrug-resistant strains of Staphylococcus aureus, to increase its serum half-life from <1 h to 24 h.
VIP has only a short-lived effect, because it is soon broken down by an enzyme called Neutral Endopeptidase
PL-3994 has an extended half-life, with reduced affinity for natriuretic peptide clearance receptors and increased resistance to neutral endopeptidase
, an endogenous enzyme that degrades natriuretic peptides.
Excessive paraneoplastic production of phosphatonin is thought to be involved in the etiology of tumor-induced osteomalacia, whereas impaired degradation and processing of phosphatonin due to endopeptidase
mutations (PHEX gene: phosphate-regulating gene with homologies to endopeptidases
on the X chromosome) is thought to cause the typical findings in XLH.
To further digest gluten, the researchers devised a similar experiment with prolyl endopeptidase
(PEP), a well-studied digestive enzyme that breaks up another gluten component called proline.
The most closely studied enzyme in this respect is the extracellular membrane bound metalloprotease, neutral endopeptidase
Gene localization of Aspartate Aminotransferese and Endopeptidase
izozymes in Wheat and Rye using developmental and organ-specific patterns.
The product peptides derived from the endopeptidase
activities of BoNTs are detected by matrix-assisted laserdesorption ionization time-of-flight mass spectrometry.