Giant cell myocarditis is most commonly diagnosed via endomyocardial
biopsy (52%), evaluation of the heart at autopsy (23%) or explantation (21%), or via examination of apical wedge sections removed at the time of ventricular assist device placement (4%).
biopsy - still useful after all these years.
biopsies (n = 5) were performed at the time of hospitalization to assess the potential causes of IDCM (8).
fibrosis (EMF), despite being the most common restrictive cardiomyopathy worldwide, still remains poorly understood.
The technique of Endomyocardial
biopsy was first described in 19741.
He has published several outstanding research papers on endomyocardial
fibrosis Cardiac Surgery, Bio Materials & Artificial Internal Organs, Health & Health Policy.
biopsy revealed oedema, with scarce and scattered interstitial lymphoid infiltrate, no evidence of thrombotic lesions or vasculitis, cardiomyocytes of varying sizes with large oval nuclei, round and irregular, no deposits of amyloid-like material, in a pattern considered non-specific.
biopsies showed no signs of acute cellular or humoral rejection, and Luminex analysis of donor-specific antibodies was negative.
biopsy is the gold standard for diagnosis of myocarditis, it is an invasive procedure with diagnostic yield of only 10 to 20 percent.
These include toxicity (medications or alcohol), cancer therapy, infiltrative, storage disease, and endomyocardial
, inflammatory, autoimmune, endocrine, and neurologic diseases.
Endocarditis, myocarditis, pericarditis, intracardiac thrombus, endomyocardial
fibrosis, coronary arteritis, myocardial infarction and valvular disease are among the cardiac manifestations .
1] It is thought to be the result of an arrest in the normal endomyocardial
embryogenesis, which leads to the persistence of intertrabecular recesses and the development of a spongy myocardium.
Evaluation of postmortem endomyocardial
biopsy specimens from 38 patients with lymphocytic myocarditis: implications for role of sampling error.
biopsy in hemochromatosis: clinicopathologic correlates in six cases.
Citation: "Optimized Delivery System Achieves Enhanced Endomyocardial
Stem Cell Retention"; A.