The Company is currently conducting a ZoptEC (Zopt arelin doxorubicin inE ndometrialC ancer) Phase 3 trial in women with advanced, recurrent or metastatic endometrial cancer
, while Phase 2 trials in ovarian and prostate cancer have been completed.
Women may have taken oral bisphosphonates because they had high fracture risk due to low endogenous estro gen from low weight, which is associated with low endometrial cancer
The women were followed until last known contact, death, or endometrial cancer
Additionally, women were excluded if diagnosed with endometrial cancer
in situ (n = 21) and sarcoma (n = 10) during follow up.
A number of biological mechanisms link obesity to endometrial cancer
This is an important public health issue because the incidences of both endometrial cancer
and obesity, a well-known risk factor for endometrial cancer
, are rising in the US.
This more comprehensive approach provides a clearer picture of the way particular endometrial cancers
will behave and will be important to gynecological oncologists who treat this disease.
In the pilot study, the test was able to accurately detect each of 24 endometrial cancers
, a 100 percent success rate, according to results published in the US journal "Science Translational Medicine.
This set of three genes is mutated in 40% of the serous endometrial cancer
tumors and in 15% to 26% of the other endometrial cancer
There are two main types of endometrial cancers
Biennial questionnaires ascertained endometrial cancer
diagnoses during the preceding two years.
Clinical studies have also shown that Mirena can help women with excessive menstrual bleeding avoid hysterectomies, can reduce pain associated with endometriosis, and may prevent the development of endometrial cancer
In each of the studies, women who consumed the highest dietary intake of soy had a lower risk for endometrial and ovarian cancers compared with the women who had the lowest intake (odds ratio for endometrial cancer
Using the sequential therapy, 1 000 women would develop 8 extra cases of endometrial cancer
over a 10-year period, whereas the same number of women over the same number of years using continuous therapy would be likely to develop 4 cases.
Researchers in oncology, obstetrics and gynecology, pathology, and radiology synthesize the current understanding and management of endometrial cancer
, radically updating the previous such general study, which was published 20 years ago.