Our intent was to evaluate the molecular weight and amount of CD117 in endometrial tissue to confirm antibody specificity, as well as to potentially identify aberrant forms (ie, truncations) of this growth factor receptor in endometria
Sheth et al, (39) however, evaluated pulsed Doppler in postmenopausal women with thickened endometria
and found that low-impedance arterial flow did not differ significantly between benign and malignant lesions.
On the other hand, type 2 carcinomas occur in older women, are usually found in atrophic rather than hyperplastic endometria
, are unrelated to estrogenic abnormalities, have p53 rather than PTEN irregularities, are often diagnosed with disseminated disease, and have a much poorer prognosis.
These experiments were conducted using endometria
from three individual gilts on D12 of the estrous cycle.
On the other hand, none of the normal endometria
and nonatypical endometrial hyperplasias in our study showed any positivity for p53.
In a second study, the presence of any vessel entering the endometrium was noted in 97 such women, while a third study documented the presence of any vascularity in the endometria
of 91 women.