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Key clinical point: Adjuvant endocrine therapy should be lengthened to 10 years.
Most clinicians treating breast cancer will have encountered women from time to time who believe that their endocrine therapy is affecting their cognitive function.
The study, which evaluated samples from more than 1,400 patients enrolled in the Austrian Breast & Colorectal Cancer Study Group 8 (ABCSG8) trial, met its primary and secondary objectives and demonstrated the ability of the PAM50 test to indicate the risk of distant recurrence in postmenopausal women with hormone receptor-positive (HR+) early-stage breast cancer treated with endocrine therapy alone.
Convincing evidence does not support routine CYP2D6 testing, and women in need of adjuvant endocrine therapy should receive an aromatase inhibitor (AI).
The panel declined to add either trastuzumab or lapatinib in combination with endocrine therapy to its algorithm as preferred agents for the treatment of ER-positive, HER2-positive, metastatic disease.
The researchers suggest that doctors need to start considering heart-related side effects when they prescribe endocrine therapy for prostate cancer and might want to refer patients to a cardiologist before starting treatment.
The different modes by which ERs can stimulate cell growth and how these may lead to endocrine therapy resistance are discussed clearly and succinctly.
New published data from a large pan-European survey indicate that the majority of postmenopausal women with early breast cancer taking post- surgical endocrine therapy are not involved in making key decisions about their treatment, nor are they given sufficient information to make informed treatment choices that could affect their long-term outcome.
Final overall survival analysis of CONFIRM, a Phase III, randomized, double-blind, parallel-group, multicenter trial comparing FASLODEX 500 mg (n=362) and 250 mg (n=374) in postmenopausal women with estrogen receptor-positive advanced breast cancer whose disease progressed or recurred following prior endocrine therapy, will be presented by Angelo Di Leo, MD, Head of the Sandro Pitigliani Medical Oncology Unit.
Ensuring the supply of medicines - endocrine therapy - the need for outpatient and inpatient care ICEM.
27, 2013 /PRNewswire/ -- Agendia, a leader in molecular cancer diagnostics, announced today that researchers have identified a subset of breast cancer patients whose standard biomarker tests may incorrectly classify patients as "low risk" and benefitting from endocrine therapy.
BERLIN--Men treated with endocrine therapy for prostate cancer are at increased risk of developing and dying from several types of cardiovascular disease, according to a large observational analysis of 30,642 Swedish patients.
What is the rationale for giving endocrine therapy up front instead of chemotherapy?
Among postmenopausal women with early ER-positive breast cancer, endocrine therapy has been shown to have a greater impact on reducing annual breast cancer death rate than adjuvant chemotherapy (31% versus 20%) [2].
Our survey shows that information provided to patients about adjuvant endocrine therapy is sub-optimal", says GAEA steering committee member Yvonne WengstrE[micro]m, President of the European Oncology Nursing Society (EONS) from the Karolinska Institute, Stockholm, Sweden.