Left ventricular ejection fraction and left ventricular end-diastolic and end-systolic volumes
were evaluated by left ventricular angiography.
Professor of Medicine & Director of Cardiovascular Research at Henry Ford Health System, said: "These data clearly show that MST-188 improves left ventricular ejection fraction and end-systolic volume
, both of which are important indicators of long-term mortality and morbidity in chronic heart failure, with some effects lasting up to 2 weeks post-infusion.
Severe aortic stenosis results in 1) reduced ventricular stroke volume due to increased after load, which decreases ejection velocity, 2) increased end-systolic volume
and 3) a compensatory increase in end diastolic volume and pressure.
For example, in patients who survived the follow-up period, left ventricular end-systolic volume
fell by an average of 19.
Patients who underwent MV surgery alone also showed a significant reduction in LV end-systolic volume
, a benefit that was substantially larger in the group that received a CSD.
2]) variable; left ventricular end-systolic volume
(LVESV)>57 ml; left ventricular ejection fraction (LVEF), divided into 2 classes: a) LVEF>45%, i.
GP531 treatment, as compared to placebo, increased ejection fraction and decreased LV end-diastolic pressure, end-diastolic volume and end-systolic volume
CSD-treated patients showed dramatic improvements in left ventricular structure by three separate indices: reduced end-diastolic volume, reduced end-systolic volume
, and a reduced sphericity index indicative of a return to an elliptical ventricle shape.