increased left ventricular (LV) diameter, end-diastolic pressure
and decreased LV fractional shortening and [+ or -] dP/dt, compared to sham animals (19).
In severe aortic stenosis, myocardial oxygen demand is high, but oxygen delivery is impaired by the effects of low aortic pressure, the high LV end-diastolic pressure
and the thick myocardial wall.
is decreased from 50 mmHg (point D1), to 35 mmHg in point D2, when IABP is applied.
In hypertensive and/or diabetic heart disease (27-32) as well as in hypertrophic cardiomyopathy and other diseases causing increase of left ventricular mass (33-34),the involvement of left atrium is early and it descends from propagation of high levels of LV end-diastolic pressure
(3537), which are faithfully reproduced by Doppler velocimetric pattern found in these cases, characterized by E/A ratio >2 and deceleration time(DT)<120 msec, so-called "restrictive left ventricular filling pattern" or RFP (38).
Left ventricular end-diastolic pressure
, left atrial pressure (LAP) and pulmonary capillary wedge pressure has been the subject of many investigations.
B-type natriuretic peptide (BNP) is a neurohormone produced mainly by ventricular myocytes in response to increased end-diastolic pressure
, or volume, of the ventricles (3-5).