We present the case of a patient with generalized enchondromatosis who developed a large enchondroma
of the clivus, and we discuss the clinical presentation and potential treatments for this entity.
distal Single diaphysis histologic area suggestive of pre- existing enchondroma
2 60/M 4 (1.
If arising within the medullary cavity, they are known as enchondromas
sometimes cause dyschondroplasia of the long bones during childhood.
Somatic mosaic IDH1 or IDH2 mutations are associated with enchondroma
and spindle cell hemangioma in Ollier disease and Maffucci syndrome.
The degree of endosteal scalloping is considered the best predictor in distinguishing chondrosarcoma from benign enchondroma
MRI visualized one hydrocele, one osteoma of the left femur, one enchondroma
of the pubic bone, and one dilated left ureter without clinical symptoms or therapeutic relevance.
The patient had a biopsy and enchondroma
Low-grade chondrosarcoma can be difficult, if not impossible, to differentiate from an enchondroma
, which is the primary alternative consideration in the differential diagnosis.
On the other hand, diagnoses specific to older patients include metastasis, multiple myeloma, enchondroma
, and subchondral cysts.
For example, from clinical and radiologic interpretations of cartilaginous neoplasm such as enchondroma
versus well-differentiated chondrosarcoma, the pathologist should extract a diagnosis that includes prognostic implications as well as possible further treatment and follow-up.
Enchondromatosis, or Ollier's disease, is a rare, nonhereditary dyschondroplasia characterized by multiple, asymmetrical enchondromas
throughout the skeleton.
Chondrosarcomas may arise de novo (primary), or superimposed (secondary) upon preexisting cartilaginous lesions, such as enchondromas
Cartilaginous tumors (such as osteochondromas, enchondromas
, and chondrosarcomas) may produce irregularly shaped calcifications within their matrix that resemble popcorn on imaging studies (Figure 16).
2) Although they usually occur spontaneously, they may also arise as a result of malignant degeneration of an endochondroma, as seen in both Maffucci syndrome (a mesodermal dysplasia that causes enchondromas
and hemangiomas) and Ollier disease (which manifests as multiple enchondromas