Delivery of 5-azacytidine to human cancer cells by elaidic acid
esterification increases therapeutic drug efficacy.
CDC studied four major TFAs to provide a reasonable representation of TFAs in blood: elaidic acid
, linoelaidic acid, palmitelaidic acid, and vaccenic acid.
This drug, elacytarabine, is a novel elaidic acid
derivative of cytarabine and currently undergoing the CLAVELA phase III study for treatment of patients with relapsed/refractory AML.
The investigators assume that the elaidic acid
makes it possible even for cells without special transport proteins to take up CP-4200; the substance might reach the cell interior directly through the membrane.
15) Most human experiments have been conducted with trans 9, 18:1, called elaidic acid