A variety of methods has been used to identify active efflux
systems in bacteria, such as fluorometric assays or the determination of the minimum inhibitory concentration (MIC) for fluoroquinolones group in the presence of compounds known to modulate the activity of efflux
pumps (as efflux
pump inhibitors, EPIs)
The MexJK efflux
pump of Pseudomonas aeruginosa requires OprM for antibiotic efflux
but not for efflux
It is not known if other psychotropics have the same effect on P-glycoprotein or other efflux
These double/triple transfected models will help to improve predictions regarding efflux
interactions with poorly permeable compounds.
pump inhibitors two-fold reduction in MIC was seen in 57-100 per cent M.
Most antimicrobial agents are pumped out by these efflux
Reserpine-sensitive fluoroquinolone efflux
phenotype was determined as described (23).
whenever oxygen uptake increases (Gonzalez and McDonald, 1992; 1994).
Although promotion of cholesterol efflux
and RCT is thought to be the major mechanism by which HDL protects against atherosclerosis, the last decade has seen substantial growth in interest in other properties of HDL that may be atheroprotective.
potential) that leads to atherosclerosis and to screen new drug compositions being developed to reduce the accumulation of cholesterol or enhance the clearance of cholesterol from the vessel wall.
Over the course of a decade-long career, Michel Majerus crammed the digital efflux
of our age into paintings that strain conventional definitions of the medium.
In his letter on our recent article in EHP (Luckenbach and Epel 2005), Salvito raises important questions about effects of the synthetic musk fragrances regarding a) human and environmental health effects, b) environmental concentrations of the musks, and c) uniqueness of inhibition of efflux
transporters to the musks, the effect we described in our article.
The second form is a close approximation in terms of loss-corrected efflux
However, past studies didn't investigate the chemicals' effects on the cellular bilge pumps, which scientists call efflux
pumps, multidrug-resistance transporters, and various other names.
The researchers found that the synthetic musks inhibit efflux
transport proteins, which normally work as a first line of defense to flush cells of toxicants.