In addition, susceptibility genes of diseases related to ectopic ossification were chosen, including activin receptor-like kinase 2 (ACVR1) and COL11A2 .
We performed an analysis of candidate genes related to endochondral ossification and ectopic ossification in AS in a Chinese Han population.
Biological studies after identification of susceptibility SNPs of OPLL by GWAS would lead us to the beginning of the end for understanding this mysterious disease as well as the mystery of ectopic ossification
It is clinically characterized by two main features, anomalies of the great toes and thumbs and progressive ectopic ossification
of soft tissues causing limitation of movements.
involves new bone formation in tissue that normally does not ossify.
Radiographs showed stage 4 arthritis based on the JOA hip score, with no ectopic ossification
Brooker AF, Bowermann RA, Railey LH, ectopic ossification
following THR, Incidence and classification JBJS 55A:1629-1632, 1973.
The process of ectopic ossification
begins with the production of bone morphogenetic protein, which leads to the release of a cascade of mediators that results in the formation of bone?
His radiographs revealed arthritic changes in the hip; ectopic ossification
in the gluteal region & paraspinal region; hypoplastic 1st metatarsal and proximal phalanx (Fig 2).
Viola RW, Hastings H: Treatment of ectopic ossification
about the elbow.