Furthermore, these metabolic studies have shed light on the lipotoxicity of ectopic fat
9,29-32) Ectopic fat results in increased secretion of pro-inflammatory adipokines, hepatomegaly, and hepatocellular damage caused by toxic ceramide, apoptosis, and replacement of hepatocytes with fibroblasts.
Ectopic fat deposited within the pancreas results in a similar dysfunction, as illustrated in Figure 2.
Ventricular hypertrophy often results from leptin resistance and ectopic fat deposition within myocardial tissue.
Although abdominal obesity is not an absolute prerequisite for diagnosis of MSX, ectopic fat is extremely common and correlates with increased risk of CVD.
TG synthesis dominates the lipid buffering cycle and ectopic fat begins to accumulate
Which of the following best describes the changes that allow ectopic fat deposition when leptin resistance occurs?
We found that the associations of plasma adiponectin with plasma lipid and lipoprotein profiles, serum markers of inflammation and endothelial function, and ectopic fat accumulation become stronger with increasing adiposity.
Nevertheless, the relationship of adiponectin with ectopic fat is probably causal, because adiponectin, by activating AMP-activated protein kinase, regulates many enzymes involved in fatty acid oxidation (40).
In conclusion, we provide novel information that the associations of adiponectin with plasma lipids and lipoproteins, markers of inflammation and endothelial function, and ectopic fat become stronger with increasing adiposity.