For some moderately overweight patients with excess visceral ectopic fat
, the presence of comorbidities will determine health risk.
32-34) As seen in Figure 3B, animals that overexpress PEPCK were able to effectively buffer serum lipids when on a normal diet, minimizing ectopic fat, maintaining insulin sensitivity, and having lower serum FFAs and TGs.
Hypercaloric diets override this mechanism, resulting in leptin resistance, ectopic fat deposition, and lipotoxicity.
In leptin-deficient or leptin-resistant animals, this control is absent and ectopic fat deposition (steatosis) with consequent lipotoxicity continues unabated.
Furthermore, these metabolic studies have shed light on the lipotoxicity of ectopic fat deposition.
Leptin resistance "allows" ectopic fat deposition in liver, heart, pancreas, and muscle tissues.
9,29-32) Ectopic fat results in increased secretion of pro-inflammatory adipokines, hepatomegaly, and hepatocellular damage caused by toxic ceramide, apoptosis, and replacement of hepatocytes with fibroblasts.
This suggests that ectopic fat
accumulation in the liver may be more important than visceral fat in determining diabetic and cardiovascular risks, noted the researchers, who reported no conflicts of interest.
Two paradigms are currently areas of intense study: one focused on ectopic fat
and the other on the endocrine function of adipose tissue (2).
7- Which of the following best describes the concept of "lipid buffering" as it restricts ectopic fat
Therefore, we investigated the effect of adiposity on the relationships of adiponectin with plasma lipids and lipoprotein concentrations, inflammatory markers, and accumulation of fat in liver and muscle, commonly referred to as ectopic fat