Etomidate suppressed the immediate early genes
It functions by inducing endogenous neuroprotectants, based on the program of post ischemic genetic expression, which is regulated by the transcription factors of early genes
Also, marked up-regulation of the immediate early gene
product expression, Fos, has been found during exposure to the morphine-paired environment, (Schoeder, Holahan, Landy, & Kelley, 2000) or cocaine-paired environment (Brown, Robertson, & Fibiger, 1992; Neisewander et al.
4) The HPV E6 and E7 early genes
encode oncoproteins responsible for cervical neoplastic transformation (3) by inactivating tumour suppressors as well as promoting the accumulation of genetic mutations.
Previously it has been suggested that histone proteins have potential of being O-GlcNAc modified, which may control gene expression of immediate early genes
(Kaleem et al.
The details of the experiment can readily be found on the internet, but the salient details are that 15 early genes
were expressed in the first hour with an ongoing cascade of 77 genes 24 hours later.
Human embryo kidney cells expressing the E1A and E1B immediate early genes
of human adenovirus type 5 (HEK 293) were obtained from ATCC (CRL-1573) and grown using Dulbecco's modified minimal essential medium (Gibco, Carlsbad, CA.