GOCOVRI (amantadine) extended release capsules for the treatment of dyskinesia
in patients with Parkinson's disease receiving levodopa-based therapy, with or without concomitant dopaminergic medications
Dr Michael Lones, associate professor of computer science at Heriot-Watt University, said: "The problem is that, as Parkinson's disease worsens over time, the dose required to treat the motor features increases, which increases the risk of inducing dyskinesia
, or making it more severe and prolonged for patients who already have it.
sup] Long-term use of L-DOPA may result in several complications, including motor fluctuations and levodopa-induced dyskinesia
(LID), which cause serious distress to patients.
(TD) can occur in up to 20% of schizophrenia patients receiving long-term antipsychotics (APs) [1-4], and is associated with considerable personal suffering and social and physical disabilities.
The drug, the first to receive approval for tardive dyskinesia
in adults, will be marketed as Ingrezza by Neurocrine Biosciences.
Tardive hyperkinesias are also called Tardive dyskinesias
, are isolated involuntary dyskinesia
mainly developing in the orofacial region.
In withdrawal-emergent dyskinesia
(WE-D), which is considered a TD subtype, dyskinetic symptoms often appear shortly after rapidly reducing the antipsychotic drug dose or suddenly discontinuing the drug in a portion of patients who did not display abnormal involuntary movements during antipsychotic treatment.
Additionally, the report provides an overview of key players involved in therapeutic development for Dyskinesia
and features dormant and discontinued projects.
Accordingly, an improvement of motor symptoms, particularly of hypokinesia and on-off fluctuations, has been described in several grafted patients [4, 7-9], whereas amelioration of dyskinesia
and postural instability was not as significant [8, 10, 11].
The report reviews key players involved in the therapeutics development for Dyskinesia
and enlists all their major and minor projects
X did not report any extrapyramidal side effects, including tardive dyskinesia
This funding supports the continued development of SNC-102, a new formulation of acamprosate calcium currently being studied in a Phase 2 trial to treat moderate-to-severe tardive dyskinesia
Kartagener syndrome is an autosomal recessive disorder, a subgroup of primary ciliary dyskinesia
, characterized by a triad of bronchiectasis, sinusitis and situs inversus.
Santhera has global rights to fipamezole and has previously published promising data of its Phase IIb clinical trial in the treatment of levodopa-induced dyskinesia
in Parkinson's disease.
In the Alabama case the plaintiff, Danny Weeks, claimed he had developed a movement disorder known as tardive dyskinesia
after taking generic versions of Reglan to treat his acid reflux.