Non-hematological side effects with Dacogen were considered acceptable by the investigator, and included drug fever
in 27 patients (21 percent), diarrhea in 6 patients (5 percent), nausea or emesis in 5 patients (4 percent), fatigue in 3 patients (2 percent), cardiac events in 3 patients (2 percent) and alopecia in 2 patients (2 percent).
This patient should become afebrile within 24-36 hours" if it's drug fever
, said Dr.
Adverse events were leukopenia in four patients, pancytopenia in one patient, and drug fever
in one patient.
Also consider drug fever in the differential diagnosis.
Half of all patients with postoperative fever who undergo a complete blood count with a WBC differential will demonstrate eosinophilia, lending support to drug fever as a possible cause.