Influence of inhibitor verapamil hydrochloride P-gp on drug absorption
reported that the albendazole permeation (percent dose absorbed at 2 hours) in vitro under simulated fed and fasted conditions was in agreement with in vivo findings and concluded that the system can be used to study food's effect on drug absorption
The correlation between the drug absorption
Two previous studies have suggested that small absorptive intestinal surface area could be the primary reason for the low drug absorption
in these populations [10,13].
Serum concentrations of free 8-PN showed rapid drug absorption
and secondary peaks suggestive of marked enterohepatic recirculation.
In this article we discuss the effect of developmental changes in young children on drug absorption
, distribution, metabolism and excretion which form the basis for recommended dose estimation.
Rates of drug absorption
and excretion (which determine safety margins) often also differ between species.
At the same time it has a rich supply of microscopic blood vessels to speed drug absorption
into the system.
Tokyo, Japan, Oct 15, 2005 - (JCNN) - PharmaDesign announced on October 11 that Mochida Pharmaceutical has signed a licensing agreement with Inpharmatica, a UK drug discovery firm, for Admensa Interactive, Inpharmatica's proprietary in-silico suite of predictive drug absorption
, distribution, metabolism and excretion (ADME) models and compound prioritization tools.
Aegis' Intravail absorption agents have numerous competitive advantages, including rapid drug absorption
and onset of action, controlled transient permeation of the nasal mucosal barrier with no or minimal irritation, avoidance of gastric hydrolysis in the stomach and "first pass effect" elimination by the liver that can accompany oral administration, greater patient convenience and compliance, elimination of needlestick injuries and associated transmission of bloodborne pathogens, compatibility with current nasal delivery devices, ease of formulation and compatibility with routine homogeneous formulation and dispensing manufacturing processes for ease of scale-up and production
Studies could focus on improving drug absorption
so that smaller doses are needed and less is excreted.
For some people on a drug like lovastatin, grapefruit juice will increase their area under the curve (a measure of drug absorption
over time) by 30-fold, "but they were the people who had very low area under the curve to begin with," he said.
The enteric coating dissolves when the beadlets empty into the small intestine, the site of drug absorption
Because of potential problems with drug absorption
, amprenavir should be taken at least 1 hour before or after an antacid or didanosine (Videx).
Chapter 4 presents a clear, concise presentation of the principles of drug absorption
, distribution, metabolism, and elimination, with some useful practical applications (e.