During the initial 15 day dosing
period, there were no reports of drug-related serious adverse events or withdrawals due to adverse events.
204]Pb/kg body weight), a single oral dose of succimer, and a shorter study duration after succimer and Pb dosing
(~ 26 hr), the latter of which may not have been sufficient for complete fecal collection of unabsorbed Pb tracer.
The pups' blood lead concentrations at the times of cocaine dosing
were comparable to those common in urban children, who by socioeconomic circumstance may also be at greater risk of drug use.
The favorable tolerability profile of AVE9633 demonstrated in this first trial enables the compound to be evaluated in additional Phase I studies with a more frequent dosing
schedule better suited to the highly proliferative nature of AML.
After completing screening and single-blind placebo run-in periods, asthmatic patients who met randomization criteria were administered either 16 cumulative puffs of XOPENEX HFA (45 mcg) (n=22) or racemic albuterol HFA MDI (90 mcg) (n=27) during the first dosing
visit (Visit 4).
In addition, PRX-07034 demonstrated adequate absorption, with drug exposures increasing with increasing doses and a half-life of 14 to 24 hours, making it suitable for once-daily dosing
Because the effects of GnRH agonists are best evaluated after at least three months of dosing
, these preliminary results may be reversed by the final results of this clinical trial.
The results of this test, when used in combination with other important clinical information, should reduce the guesswork in dose selection and enable more precise determination of the final dosing
The results of these studies demonstrated that ACP-104 is safe and well tolerated after repeated dosing
of up to 600 mg per day, and that initial signals of antipsychotic effects were observed within the tolerated dose range of ACP-104.
Two combination therapy dosing
schedules were investigated in this protocol.
Efficacy endpoints of the study will include reduction in viral load after 14 days of functional monotherapy and after three months of dosing