Whereas untreated HL-60 cells exhibit a typically nonadherent, fairly round morphology, cells exposed to this abietane diterpene
display condensation and fragmentation of chromatin which is detectable after only 4 h of treatment.
Coffee components called diterpenes
may pitch in against cancer as well.
Cafestol and kahweol, two coffee specific diterpenes
with anticarcinogenic activity.
from Baccahris trimera with a relaxant efect on rat vascular smooth muscule.
Paclitaxel (PCL), a diterpene
amide derived from Pacific yew tree, the most important anticancer agent for the past 18 years.
Salvinorin A is a neoclerodane diterpene
and is the active component in plant, Salvia divinorum.
Most memorable among Wiesner's many total systheses were those of diterpene
alkaloids which were performed in a series of "generations" of increasing efficiency.
, cafestol and kahweol are the substances in coffee responsible (8) and boiled, Turkish/Greek and cafetiere coffee contain the highest levels of diterpene
Research in the past decade has identified potentially therapeutic effects for the diterpene
andrographolides in A.
de Roos B, Gaslake MJ, Stalenhoef AF, et al: The coffee diterpene
cafestol increases plasma triacyiglycerol by increasing the production rate of large VLDL apolipoprotein B in healthy normolipidemic subjects.
Stevioside, a natural sweetener and a diterpene
glycoside extracted from Stevia rebaudiana (Bertoni) has been used as an anti-hyperglycemic agent for the treatment of diabetes for decades.
FB3 is a proprietary, international patent-pending blend of Coleus forskohlii, Salacia reticulata and Sesamum indicum--standardized, respectively, for diterpene
forskolin, kotanol and salacinol, and sesamin.
Anti-angiogenic and anti-inflammatory properties of kahweol, a coffee diterpene
Anti-tumor-promoting activity of the diterpene
from Excoecaria agallocha.
Rosemary Antioxidant Extract (organic), 25% Diterpene