disulfiram


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Synonyms for disulfiram

a drug (trade name Antabuse) used in the treatment of alcoholism

References in periodicals archive ?
Disulfiram breaks down acetaldehyde, an ethanol byproduct, and should be used only to treat patients with a goal of abstinence.
Disulfiram (Antabuse) is approved by the US Food and Drug Administration (FDA) for alcohol aversion and has been used to treat alcohol addition for over six decades.
Cantex's CX-02 is a proprietary combination of disulfiram + copper.
FDA-approved pharmacotherapy for alcohol use disorder Generic Dosing Goal recommendation Disulfiram 125 to 500 mg/d Complete (250 mg/d is abstinence standard dosage) Acamprosate 666 to 999 mg, Relapse TID prevention (reduce drinking, prevent cravings) Naltrexone 50 to 100 mg/d Relapse by mouth; prevention 380 mg/month (reduce drinking, subcutaneous prevent cravings) Generic Other considerations Disulfiram 1.
3], in combination with disulfiram, is being evaluated as a second-line therapy in phase I trials (NCT00571116) in patients with metastatic melanoma.
Unlike other medications for alcohol dependence, disulfiram does not affect brain opiate, [gamma]-aminobutyric acid, or glutamate receptors directly.
Disulfiram (Antabuse) was the first medication available for the treatment of alcohol use disorder, and it remains the most widely prescribed medication in some countries.
On the other hand, clinical experience shows that while disulfiram can be useful over a certain period for people who have decided to give up drinking, it is likely that after an initial period of continuous abstinence, the alcoholic patient will try a drink, which tends to lead to relapse, just when he/she was at an advanced stage of recovery.
But GI upset is common with the drug, and, like disulfiram, it can cause liver problems.
The drug disulfiram combined with a copper supplement significantly reduced prostate tumor growth in animal models with advanced disease, researchers at Duke Medicine, Durham, NC, report.
Disulfiram has been used for decades to treat alcohol dependence; naltrexone was first approved by the Food and Drug Administration (FDA) in 1984 as a treatment for opioid dependence and then later (in 1994) as an adjunct to the treatment of alcohol dependence; and buprenorphine was approved by the FDA for treatment of opioid dependence in 2002.
Initiation: Disulfiram leads to the accumulation of a toxic metabolite of alcohol, which leads to uncomfortable physical symptoms.
Disulfiram, a drug marketed as Antabuse, blocks the enzyme that breaks down alcohol, causing nausea if the patient drinks alcohol.
Deterrent drugs include disulfiram, calcium carbide, citrated calcium carbide and nitrefazole.