However, the most common aetiology responsible for phenotype discordance between MZ twins is the involvement of epigenetic mechanisms.
Alternatively, the possibility of the discordance of the female MZ twins resulting from the differential expression of their maternal and paternal chromosomes is not novel.
The prevalence of discordance of the shape and size of teeth in pairs of MZ and DZ twins has also been studied, and the results have been controversial.
Using the setting of an area with limited medical resources, we evaluated the concordance and discordance
of telepathology versus traditional microscopy when used for rendering an accurate diagnosis.
In our study, although the numbers were small, patients with human immunodeficiency virus had a very low discordance rate.
Key Words: autopsy rate, clinical pathologic discordance, internal medicine residency programs
Studies have consistently demonstrated the importance of autopsies in determining correct pathologic diagnoses and in identifying clinical pathologic discordance.
The purpose of this study was to evaluate the rate of concordance of histologic types of lung cancer diagnosed in cytology and biopsy specimens obtained during a single bronchoscopic procedure, to evaluate the cause of discordance, and to correlate discordance with patient outcome.
Cytologic and histologic diagnoses were then compared, and cases with remaining discordance were submitted for independent evaluation to a second pulmonary pathologist (E.
First, it is a cross-sectional study and therefore cannot predict the development of coronary artery disease, nor can it predict the effects of cholesterol-lowering therapy in the concordance and discordance
The finding that discordance
is more often explainable by failure of the liver biopsy than by errors in the markers might be considered as evidence that fibrosis markers are more accurate than biopsy.
The aims of this study were (a) to prospectively assess the quality of biopsy in a large hospital-based cohort; (b) to prospectively assess the prevalence and the factors associated with significant discordances between liver biopsy estimates and FT-AT estimates; (c) to attribute the cause of discordances to biopsy or to FT-AT; and (d) to detect possible causes of failures attributable to FT-AT in a large community-based population by analyzing the distribution of the six components of FT-AT.
The first, a hospital-based cohort of patients with chronic hepatitis C from our institution, was included prospectively from January 1997 to December 2002 to assess biopsy quality, discordance rate, and the factors associated with discordance and to attempt to attribute the causes of discordances (biopsy or FT-AT).
Discordances between cTnT and cTnI were observed in 6 of a total of 18 samples in sample I and persisted in 5 of these in sample II at either cutoff value.
Discordances between cTnI and cTnT (increased cTnT) were observed in a patient with amyloid cardiomyopathy and one patient with chronic obstructive pulmonary disease complicated with pneumonia.