Another topical issue regarding the safety of directed donor
blood relates to the risk of graft-versus-host disease when patients who receive blood share an HLA haplotype with an HLA-homozygous blood donor.
The system that we have set up now relies to a significant extent on self-help: on mobilizing friends and family members to donate kidneys, even when this mobilization can go so far as to cross the line into coercion of directed donors
The plaintiffs said they had been refused the option of using directed donor
Exceptions from the requirement include autologous HCT/Ps and reproductive cells or tissues from a directed donor
, those for use in first- or second-degree blood relatives, and those that meet a documented urgent need.
Several of the larger organizations in Give Local America extended, rescheduled the event or directed donors
to the organizational website.
Results: Our study population mostly constitute directed donors
as compared with voluntary donors.
In addition, directed donors
are under pressure to donate.