a biotechnology company developing therapeutics to dilate
human veins and arteries for use in vascular surgery and angioplasty, announced today that it has raised $19 million in a Series A venture capital round.
In patients with certain types of debilitating congestive heart failure, the left ventricle dilates
and becomes severely weakened.
It then dilates
the blood vessels and helps the oxygen get to cells that need it.
Nitric oxide inhalation's therapeutic potential as a selective pulmonary vasodilator (a drug that dilates
blood vessels only in the lung) was evaluated in multi-center clinical trials sponsored by the National Institute of Child Health and Human Development (NICHD), Massachusetts General Hospital (MGH) and Ohmeda.
Moreover, those compounds caused unwanted side effects by stimulating two other kinds of beta-adrenergic receptors, one that raises heart rate and another that dilates
blood vessels (SN: 5/7/94, p.
Researchers have long known that nitric oxide from blood vessel walls relaxes and dilates
But unlike other such drugs, it also dilates
blood vessels and serves as an antioxidant.