Dibucaine is a competitive inhibitor of BChE and is used to determine an individual's DN, which is the percentage of BChE inhibited by dibucaine.
A method for the detection of atypical forms of human serum cholinesterase; determination of dibucaine numbers.
Such agents include benzocaine, butamben, cocaine, dibucaine
, lidocaine, pramoxine, prilocaine, tetracaine, and dyclonine (a bactericidal and fungicidal local anesthetic used in lozenges and throat sprays for sore throats).
Dibucaine often is found in topical ointments used to treat sunburn, cuts and hemorrhoids.
Parents should keep all medications containing dibucaine, as well as lidocaine, another anesthetic, out of the reach of children, he advised.
Hence, the identification of individuals with inherited BCHE variants remains within the province of the laboratory because the demonstration of low plasma cholinesterase activity (BCHE) and abnormal enzyme phenotype (defined by responses to dibucaine and fluoride inhibitors) quantify the degree of impairment and confirm its hereditary basis.
703] [right arrow] Gly), or dibucaine point mutation in exon 2, the most extensively studied.
inhibition test can identify such variants.
4) For >30 years, serum BCHE activity, dibucaine
number (DN), and fluoride number (FN) have provided sufficient information to identify most of the known BCHE phenotypes associated with succinylcholine sensitivity .