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In other microorganisms, point mutations in the DHFR gene are an important mechanism of drug resistance.
High-level pyrimethamine resistance results from the accumulation of mutations in the dhfr gene, principally at codons 108, 59, and 51 (5,6).
Linkage of ISCR3, ISCR9, and ISCR10 to sul2 and dhfr genes was not demonstrated.
Because dhfr genes are associated with ISCR elements, we also performed molecular analysis of them.
The sul2 gene and dhfr genes are often found on plasmids and in close association with class 1 integrons or ISCR mobile genetic elements (10,15,18,19).