A statement available on the website of Crocidin - the syrup Phelps took - describes the abuse of over-the-counter products including those that contain dextromethorphan
as a "long-standing issue" and says the cough suppressant is safe when used as directed.
and quinidine in combination has demonstrated significant reduction in PBA symptoms.
The 93 patients randomized to the investigational treatment started on 20 mg dextromethorphan
and 10 mg quinidine administered orally once daily for a week, followed by an up-titration schedule over 2 weeks to reach 30 mg dextromethorphan
twice daily plus 10 mg quinidine twice daily, the dosage they continued for an additional 7 weeks.
A separate report at the meeting presented a new analysis of data from an open-label study that examined the same dextromethorphan
plus quinidine formulation to treat 134 patients for 12 weeks with PBA secondary to dementia, stroke, or traumatic brain injury.
But in the new study, dextromethorphan
was as effective at easing pain in the 14 women with fibromyalgia as it was for 10 women without the condition.
, dextrorphan, quinidine, chlorpheniramine, [beta]-nicotinamide adenine dinucleotide phosphate (NADP), D-glucose 6-phosphate, glucose 6-phosphate dehydrogenase, heparin sodium, urethane, and phenacetin were from Sigma Chemical Co.
Methods: Therapeutic equivalent doses of codeine, dextromethorphan
and dextropropoxyphene were given orally.
is the most commonly used over-the-counter remedy for children's coughing and is the main ingredient in brand name cough suppressants such as Benylin, Robitussin, Sucrets and Vicks.
(often abbreviated as "DM") can cause neurological problems, including hallucinations and abnormal movements in infants.
is the active ingredient in many cough mixtures.
2004) conducted a double blind, placebo-controlled clinical trial testing the effectiveness of dextromethorphan
and diphenhydramine in treating nocturnal cough and sleep difficulty in children experiencing symptoms of upper respiratory infections.
All Stop & Shop Supermarket pharmacies now restrict sales of cold and cough medicines containing dextromethorphan
, a synthetically produced ingredient in a number of over-the-counter products.
Ahold USA said yesterday that starting May 20, its retail pharmacies will voluntarily place an age restriction of 18 years or older on buyers of medications containing dextromethorphan
, prompted by what it said was "a disturbing trend of abuse of these products by young people.
Two of the infants (patients 2 and 3) had detectable blood levels of dextromethorphan
(a cough suppressant) and acetaminophen (an antipyretic and analgesic).
Delsym is made with a patented time-release formulation that allows the cough suppressant dextromethorphan
to be available in the body over a 12-hour period.