Specialists in toxicology, occupational health, pathology, and reproductive medicine survey the current state of computational methods in reproductive and developmental toxicology
1 Receptor Biology Section, and 2 Reproductive Medicine Group, Laboratory of Reproductive and Developmental Toxicology
, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA; 3 Taconic Inc.
The developmental toxicology
of animals is also included for comparative purposes and because they sometimes have been predictive of human potential for toxicity.
Jeanne Stadler, a well-known consultant who specializes in reproductive and developmental toxicology
As some background, I currently serve as program director of the Environmental Diseases and Medicine Program, chief of the Laboratory of Reproductive and Developmental Toxicology
, and chief of the Receptor Biology Section at the NIEHS.
is the study of hazard and risk associated with exposure to toxicants during prenatal development and effects on the developmental process until puberty, while reproductive toxicology is the study of adverse effects of toxicants on the reproductive processes of both sexes and the causes of such effects.
Recent developments in regulatory requirements for developmental toxicology
The National Research Council Committee on Developmental Toxicology
(NRC 2000) has suggested that model organisms such as those listed above for which the outcome of a perturbation in a specific signaling pathway is easily measured could be used as preliminary screens for toxicity.
Reproductive and Developmental Toxicology
is a comprehensive and authoritative resource providing the latest literature enriched with relevant references describing every aspect of this area of science.
It has since evolved into an advanced aquatic animal facility with laboratories supporting four core research areas: signal transduction and endocrine disruption, metals toxicology and neurotoxicology, the use of zebrafish as a model organism for developmental toxicology
, and behavioral toxicology.