Associated hazards include: acute toxicity, neurotoxicity, kidney toxicity, liver toxicity, reproductive / developmental toxicity
This study is focused on developmental toxicity
of Cr VI.
Study designs and outcomes investigated by current guidelines and our proposed protocol on carcinogenicity and chronic toxicity and reproductive and developmental toxicity
are summarized in Table 1.
However, an analysis of 1,154 drugs found that animal data raised the possibility of human developmental toxicity
in 311 drugs, which was eventually confirmed in 75 drugs (Am J Obstet Gynecol.
Studies with other species also showed developmental toxicity
caused by metolachlor and its metabolites.
Although miltefosine caused severe toxicity in two animal species, visceral and cutaneous leishmaniasis may be life threatening for the mother and can cause severe developmental toxicity
in the embryo and fetus, so the drug should not be withheld in pregnancy.
An assessment of the developmental toxicity
of inorganic arsenic.
Scientists from the US and Canada describe the impact of methanol on the environment; human toxicity, including exposure, metabolism, in utero exposure, controlled human studies, and management of methanol poisoning; animal and aquatic toxicity, including acute toxicity, irritation, sensitization, and repeat exposures; the developmental and reproductive toxicology of methanol and the pathogenesis of methanol-induced birth defects; differences between PBPK (physiologically based pharmacokinetic) models of methanol disposition in mice and humans; oxidative stress and species differences in the metabolism, developmental toxicity
, and carcinogenic potential of methanol and ethanol; and methanol and cancer.
Tests such as acute toxicity, Skin sensitization, carcinogenicity and reproductive and developmental toxicity
tests which have been performed on animals have been replaced by existing data, 3D human skin models, in vitro genotoxicity tests on target cell models and other non-animalbased methods.
Mr Ahmed said unfortunately, only a small percentage of the 100,000 existing chemicals had been tested for potential health effects, such as cancer, reproductive and developmental toxicity
, or impacts on the immune system.
In addition to elevated cancer risks and disruption of the endocrine system, increasing evidence supports developmental toxicity
from prenatal or early postnatal exposure to PAHs.
Things like formaldehyde, naphtha, methylene chloride, and perchloroethylene are highly toxic to humans, including carcinogenicity, reproductive and developmental toxicity
, neurotoxicity, respiratory irritation and acute toxicity.
Due to the number of new substances coming into use every year and the increasing amounts of chemicals, which are introduced into the environment, there is a high demand for a rapid, reliable and cost-effective method for detection of developmental toxicity
The 27 chapters by a group of North American pharmacists, physicians, and nurses specializing in maternal-fetal medicine provide information often lacking in pharmacy training, including discussion of physiologic changes, developmental toxicity
, drug use and lactation, use of over-the-counter medications, teratology risk assessment and counseling, drug therapy for complications unique to pregnancy, and treatment of common chronic diseases such as depression, epilepsy, infectious disease, nausea and vomiting, and autoimmune diseases in pregnancy.
The current study was performed to confirm the developmental toxicity
of the ionic liquid 1-decyl-3-methylimidazolium chloride ([C10mim]Cl).