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Desipramine pharmacokinetics when coadministered with paroxetine or sertraline in extensive metabolizers.
Desipramine and nortriptyline appear to be better tolerated in the elderly due to fewer anticholinergic effects.
In this experiment, the mice were divided into six groups in six cages, including control group, desipramine group, YZ-30 group, YZ-50 group, YZ-70 group and YZ-95 group.
In human patients with a type of depression called melancholic depression, fluoxetine/Prozac doesn't work as an antidepressant but desipramine does work.
A Tricyclic antidepressants (TCAs), such as amitriptyline (Amitril, Elavil), desipramine (Norpramin), doxepin (Adapin, Sinequan), imipramine (Tofranil) and nortriptyline (Pamelor, Aventyl), are commonly used to treat chronic pain.
Despite their success rate, these still fail in 25% of cases, and may have many unwanted side effects (such as tics), forcing a search for second line agents such as drugs that affect the noradrenalin and serotonin systems, noradrenalin reuptake inhibitor desipramine and others.
The possible roles of these two major pathways in regulation of the hematopoiesis processes were examined by using pharmacological agents such as desipramine and 6-OHDA in order to determine their effects on the hematological parameters.
The circulating neurotransmitters noradrenaline, adrenaline, dopamine, platelet serotonin, plasma serotonin, and tryptophan were assessed before and after a desipramine challenge (10 mg injected intramuscularly) in patients affected by neural sympathetic predominance (N), adrenal sympathetic predominance (A), and normal controls (C).
The addition of desipramine to buprenorphine or methadone may augment or facilitate abstinence from cocaine and opioids in patients dependent on both substances (Kosten et al.
Antidepressants, such as the selective serotonin reuptake inhibitors (SSRIs) including sertraline hydrochloride (Zoloft) and fluoxetine hydrochloride (Prozac), citalopram (Celexa), escitalopram (Lexapro) and paroxetine (Paxil); selective noradrenaline reuptake inhibitors (SNRIs), including venlafaxine (Effexor) and duloxetine (Cymbalta); and tricyclic antidepressants, including amitriptyline (Elavil), nortriptyline (Pamelor), desipramine (Norpramin), and imipramine (Tofranil); and atypical antidepressants such as bupropion (Wellbutrin) and trazodone (Desyrl)
The administration of hypertonic sodium chloride to rats with desipramine toxicity has been shown to be as effective as sodium bicarbonate in reversing QRS prolongation and hypotension (8).
imipramine and desipramine, are effective in controlling behaviour and improving cognitive impairments but are less effective than the stimulants.
I am currently taking Desipramine on a trial basis.
However, the analysis of a Seronorm Pharmaca level 1 internal quality control by this extraction procedure and the present GUS method showed that some compounds were not detected, in particular nortriptyline and desipramine, although their presence had been confirmed by a quantitative LC-MS/MS technique in the multiple reaction monitoring mode developed for this purpose (Table 1).
Examples include doxepin (Adapin, Sinequan), amitriptyline (Elavil), desipramine (Norpramin) and nortriptyline (Pamelor).
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