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Both types may be mistaken for squamous neoplasia or other lichenoid interface dermatitides with epidermal hyperplasia, particularly in superficial biopsies interpreted in the absence of adequate clinical information.
Primary interface dermatitides in this group include hypertrophic lichen planus (HLP) and lichenoid drug eruptions (LDEs).
Other disorders with prominent epidermal hyperplasia and inflammation not considered primary interface dermatitides may rarely enter the differential of HLE.
These cases were numbers 06 (necrobiosis lipoidica) and 08 (botryomycosis) for the ND dermatitides and numbers 05 (epidermolysis bullosa dermolytic) and 08 (systemic lupus erythematosus) for the SV dermatitides, as listed in Table 1.
This process, termed pseudoepitheliomatous hyperplasia (PEH; or pseudocarcinomatous hyperplasia), is potentially associated with organoid nevi, nonhealing ulcers, chronic dermatitides, reactions to underlying neoplasms, and selected infections of the skin.