A notable correlation exists between conditions that decrease the number of serotonin neurons or nerve terminals in the dentate gyrus
and factors that decrease neurogenesis, which suggests that this neuro-transmitter is important in the regulation of adult NSCs.
One group had a normal dentate gyrus
, and the other was incapable of neurogenesis because researchers had knocked out the dentate with X-rays.
Immediately before birth the levels of glucocorticoids are high and the number of dentate gyrus
granule cells that incorporate [sup.
Adult brains make new nerve cells, or neurons, in the dentate gyrus
, part of the hippocampus--a seahorse-shaped region that plays an important role in learning and memory.
Besides improvements on the memory test -- a pattern recognition test involving the kind of skill used in remembering where you parked the car or recalling the face of someone you just met -- researchers found increased function in an area of the brain's hippocampus called the dentate gyrus
which involves memory.
Both functions involve the dentate gyrus
region of the hippocampus, which is especially susceptible to age-related changes.
Chen said that this neurotransmitter, called GABA (gamma-aminobutyric acid), was found in deformed cells called "reactive astrocytes" in a structure in the core of the brain called the dentate gyrus
, whose structure is the gateway to hippocampus, an area of the brain that is critical for learning and memory.
Through these electrical recordings of nerve cell activity, they focused on a region of the hippocampus known as the dentate gyrus
thought to contribute to the formation of new memories.
In a mature brain, neuron formation slows considerably, but extends into later life in dentate gyrus
and olfactory bulb.
1A]ARs) increases the number of proliferating cells in the subgranular zone (SGZ) of the adult dentate gyrus
and enhances learning and memory in the mouse.
The sections include (1) middle frontal gyrus; (2) superior and middle temporal gyri; (3) inferior parietal lobule; (4) occipital cortex; (5) anterior cingulate gyrus; (6) amygdala; (7) hippocampus with dentate gyrus
and entorhinal cortex; (8) basal ganglia at the level of the anterior commissure with caudate, putamen, globus pallidus, and the nucleus basalis of Meynert; (9) thalamus with subthalamic nucleus; (10) cerebellar cortex and dentate nucleus; (11) midbrain with substantia nigra; (12) pons with locus coeruleus; (13) and medulla with dorsal motor nucleus of the vagus and hypoglossal nucleus.
Germ-free mice also exhibited an up-regulation of the brain-derived neurotrophic factor in the dentate gyrus
of the hippocampus, as well as down-regulation of 5HT1A receptors and NMDA receptor expression, all of which have been associated to the stress response and to emotional behavior (Neurogastroenterol.
The scientists set about trying to find compounds that might protect vulnerable growing neurons in the dentate gyrus
, a key area of the hippocampus.
It is enclosed by the narrow, dark band of cells of the dentate gyrus
2005) showed that Rhodiola rosea had a protective effect on the hippocampus and dentate gyrus
of cerebral ischemia-reperfusion in injured rats.