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destroy the myelin sheath of

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Other than typical localizations, sporadic cases exist involving demyelinated plaques in the cervical spinal cord, midbrain, medulla, internal capsule, and cerebral peduncle, even cases of MS not explainable by anatomical evidence have been reported (6,7).
6) As tracked by MRI, PML lesions typically first appear subcortically in the frontal and parietal lobes; however, demyelinated plaques can also be observed in deep gray structures, the cerebellum, brainstem, and even the spinal cord.
The neuropathological interpretation of an individual active lesion is further complicated by the superimposition of inflammatory activity on previously demyelinated or remyelinated tissue, a phenomenon that increases with disease duration and in part may explain the prevalence of failed remyelination in longstanding, secondary progressive disease.
Waxman was inspired to devote his life to studying nerve impulse conduction in normal, demyelinated, and regenerating nerve fibers.
The decrease in impulse conduction velocity in demyelinated fibers is clinically relevant.
Osamy Honmou was part of the team that showed that transplantation of Schwann cells into the demyelinated rat spinal cord could improve the function of the injured spinal-cord axons.
For the last several years, researchers knew from MRI studies that the cortex was damaged very early after onset of MS, and they knew from autopsy studies that the cortex was demyelinated, as was white matter.
Researchers suspect that cognitive problems are caused by abnormal electrical activities of the demyelinated axons extending from hippocampal cells, but until now have not been able to test myelin's role in this part of the brain.
Acute polyradiculoneuritis associated with demyelinated plaques in the central nervous system: Report of a case.
We now know that when nerve fibers are demyelinated because of MS, they lose their ability to conduct nerve impulses--resulting in the "short-circuiting" that causes the various symptoms.
These demyelinated spinal-cord axons include descending motor fibers, which carry information necessary for the control of muscle power from the brain downward through the spinal cord, and sensory fibers, which carry ascending sensory messages through the spinal cord to the brain.
When axons lose their insulation, however, either signal conduction fails because the demyelinated axons are unable to generate an impulse, resulting in a loss of sensation, weakness, or blindness, or the axons become hyperexcitable and overcompensate by firing even in the absence of an input, causing twitching.
The physical basis is no fully understood but the phenomenon suggests that a condition builds up with repetitive use of nerve fibers that have demyelinated sections (where MS has done damage).
The absence of sodium channels in bared internodal axon membranes is one of the reasons electrical impulses cannot be conducted successfully along demyelinated axons.