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destroy the myelin sheath of

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Other than typical localizations, sporadic cases exist involving demyelinated plaques in the cervical spinal cord, midbrain, medulla, internal capsule, and cerebral peduncle, even cases of MS not explainable by anatomical evidence have been reported (6,7).
The neuropathological interpretation of an individual active lesion is further complicated by the superimposition of inflammatory activity on previously demyelinated or remyelinated tissue, a phenomenon that increases with disease duration and in part may explain the prevalence of failed remyelination in longstanding, secondary progressive disease.
The effects of 4-aminopyridine and tetraethylammonium ions on normal and demyelinated mammalian nerve fibers.
Waxman was inspired to devote his life to studying nerve impulse conduction in normal, demyelinated, and regenerating nerve fibers.
The decrease in impulse conduction velocity in demyelinated fibers is clinically relevant.
For the last several years, researchers knew from MRI studies that the cortex was damaged very early after onset of MS, and they knew from autopsy studies that the cortex was demyelinated, as was white matter.
Researchers suspect that cognitive problems are caused by abnormal electrical activities of the demyelinated axons extending from hippocampal cells, but until now have not been able to test myelin's role in this part of the brain.
Acute polyradiculoneuritis associated with demyelinated plaques in the central nervous system: Report of a case.
We now know that when nerve fibers are demyelinated because of MS, they lose their ability to conduct nerve impulses--resulting in the "short-circuiting" that causes the various symptoms.
When axons lose their insulation, however, either signal conduction fails because the demyelinated axons are unable to generate an impulse, resulting in a loss of sensation, weakness, or blindness, or the axons become hyperexcitable and overcompensate by firing even in the absence of an input, causing twitching.
The physical basis is no fully understood but the phenomenon suggests that a condition builds up with repetitive use of nerve fibers that have demyelinated sections (where MS has done damage).
Transplantation of the OPCs seven days after injury led to remyelination or "reinsulation" of demyelinated axons at the lesion site.
By two months of age, the nerves were extensively demyelinated, and the mice were more sensitive to pain.
Stephen Waxman, have been studying drugs that might restore function to demyelinated nerves.
In a spinal cord contusion injury, neurons that are spared during the initial injury can be demyelinated during the subsequent inflammatory response.