Graur, John and Rebecca Moores Professor of Biology and Biochemistry at UH, took a deceptively simple approach to determining how much of the genome is functional, using the deleterious
mutation rate - that is, the rate at which harmful mutations occur - and the replacement fertility rate.
mutations confer an ovarian cancer risk of approximately 39%-46%; and the risk of ovarian cancer is roughly 12%-20% for patients with BRCA2 deleterious
as a monotherapy in patients with deleterious
or suspected deleterious
germline BRCA-mutated advanced ovarian cancer who have been treated with three or more prior lines of chemotherapy.
Methods: Most deleterious
nonsynonymous single nucleotide polymorphisms in the coding region of the ADIPOQ gene were investigated using SNP databases, and detected nonsynonymous variants were analyzed in silico from the standpoint of relevant protein function and stability by using SIFT, PolyPhen-2, PROVEAN and MUpro, I-Mutant2.
Referring to a previous conversation he had with the Labour leader, Charles wrote: "We briefly mentioned the European Directive on Herbal Medicines, which is having such a deleterious
effect in this country by effectively outlawing the use of certain herbal extracts.
The study found that almost 15 percent of triple-negative breast cancer patients had deleterious
mutations in predisposition genes.
Geneticists long have bet on the success of sexual reproduction over asexual reproduction based, in a large part, on the process known as Muller's ratchet, the mechanism by which a genome accrues deleterious
and irreversible mutations after the host organism has lost its ability to carry out the important gene-shuffling job of recombination.
Photoprotection is essential to prevent the deleterious
effects of ultraviolet (UV) light, including skin cancer, photoaging and immunosuppression.
1) leading to an unquantified but deleterious
effect on the protein product.
The archbishop further noted the deleterious
effect this would have on workers, many of whom would feel pressured to work on Sunday.
McNair underscores the causality connection between unfettered individualism and divorce, the deleterious
impact of television and movies upon family life, issues of discipline, self-esteem, suicide, homework, sexual abuse, homosexuality, and the many stresses and demands placed upon contemporary families by the broader culture.
Articles from fall of 2002 to winter of 2006 discuss topics ranging from a discussion of the value of the Head Start program to the extremely deleterious
effects of associating with thieving, harmful or shifty individuals in the realm of business (as one of Aesop's fables warns, "You are judged by the company you keep"), to disaster preparedness lessons that can be drawn from the devastation left by hurricane Katrina.
The deal with the ACS could do something to assuage concerns among some downtown landlords that the millions of square feet of development planned for the World Trade Center site will have a deleterious
effect on the Lower Manhattan office market.
Health-conscious food buyers worry about the potential deleterious
effects of pesticides and chemical fertilizers.
The line for the unders from the primary screen also has an air separation system before a model of water separation tank from Lubo, which incorporates a starscreen in it to remove deleterious
material from the wood that floats out.