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Single-nucleotide polymorphism identification assays using a thermostable DNA polymerase and delayed extraction
MALDI-TOF mass spectrometry.
However, when the delayed extraction
method (15), which is not available in our laboratory, is used, the same sample from a healthy subject leads to the spectrum shown in Fig.
Furthermore, Delayed Extraction
makes it much easier to obtain high quality spectra by Matrix-Assisted Laser Desorption/Ionization (MALDI) since laser intensity and other parameters are much less critical.
These patent portfolios relate to MALDI-TOF mass spectrometry and cover the significant technology called Space-Velocity Correlation Focusing (SVCF), or Delayed Extraction
One unique aspect of this technology lies in the use of PerSeptive's newly developed (patent pending) mass spectrometry technology called Delayed Extraction
Matrix Assisted Laser Desorption Ionization Time of Flight (DE-MALDI/TOF) mass spectrometry.