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  • noun

Words related to dedifferentiation

the loss of specialization in form or function

References in periodicals archive ?
Is tubulocystic carcinoma with dedifferentiation a form of hlrcc/ fumarate hydratase-deficient rcc?
14) In fact, postsurgical recurrence rate of glomus tumor is approximately 10%, and malignant transformation after recurrence or dedifferentiation, although exceptional, has been described.
Dedifferentiation of prostate cancer grade with time in men followed expectantly for stage T1c disease.
Through a dedifferentiation technique, the stem cells were grown in a controlled environment to be forced to synthesize secondary metabolites as a defense reaction to a controlled stress, according to Claire-Marie Grizaud.
For indirect somatic embryogenesis, dedifferentiation occurs from the explants and consequently leads to callus formation.
Cancer may arise both from genetic or environmental factors that lead to aberrant growth regulation of a stem cell population, or by the dedifferentiation of more mature cell types.
It apparently does not require dedifferentiation, but involves "reprogramming" by introduction of three genes whose expressions are typically restricted to embryonic cells.
Since dedifferentiation is an interesting phenomenon probably occurring in a lot of different stem cell populations, we wanted to know more about the process.
Progressive histological dedifferentiation in typical cases of KS has been noted [42].
While the modern societies were characterized by differentiation, the postmodern societies are characterized by dedifferentiation, the collapse of the power of distinctions.
Against the background of views on social dedifferentiation and the end of the book I emphasise the career value of the humanities.
The decision to approach the treatment of this tumor with the presumption of either dedifferentiation to or simultaneous presentation with a high-grade neuroendocrine tumor was influenced by the overall picture and history of the patient.
For this, the reason seems to be that speaking of the more differentiated sensory domain in terms of a less differentiated one is a powerful means of dedifferentiation.
This objection presumably means that there is no ethical difference between stopping the dedifferentiation process before the cell can become an embryo, on the one hand, and creating a cloned embryo and then destroying it, on the other.
The four possible approaches include extraction of cells from embryos in which cell division has stopped; biopsy of living embryos; extraction of cells from artificially created nonembryonic but embryo-like cellular systems; and dedifferentiation of somatic cells back to pluripotency.