In this phase 3 clinical trial, when Genasense was combined with dacarbazine
, the most frequent serious adverse event occurring in more than 5 percent of patients was fever (5.
Genasense plus dacarbazine
yielded superior results in a large randomized trial," said Dr.
Doxorubicin and dacarbazine
chemotherapy was started after a left above-knee amputation.
reported that Zelboraf and Yervoy have replaced older agents in the first-line advanced melanoma setting compared to major European markets where respondents are still more likely to utilize Merck's Temodar/Temodal and generic dacarbazine
in this patient population.
5 months for dacarbazine
representing a significant benefit (HR 0.
July 22, 2015 /PRNewswire/ -- AstraZeneca today announced that the Phase 3 SUMIT study of selumetinib in combination with dacarbazine
for the treatment of patients with metastatic uveal melanoma did not meet its primary endpoint of progression free survival.
It has been compared to dacarbazine
(DTIC), standard melanoma therapy, in a clinical trial with longer follow-up than the ipilimumab trial.
The standard treatment of advanced melanoma has for many years been single-agent dacarbazine
Genasense, the company's lead compound, has received "Fast Track" designation from the Food and Drug Administration, and the combination of Genasense plus dacarbazine
is currently undergoing a Phase 3 trial in patients with advanced melanoma.
Array anticipates top-line results for the Phase 2 trial with selumetinib in combination with dacarbazine
alone as first-line treatment in patients with BRAF-mutant melanoma to be reported in 2012.
Participants were randomly assigned to receive either Yondelis (345 patients) or dacarbazine
(173 patients), another chemotherapy drug.
compared to dacarbazine
in patients with advanced liposarcoma (LPS) or leiomyosarcoma (LMS) previously treated with an anthracycline and at least one additional chemotherapy regimen.
Study 309 is a randomised, open-label multicentre Phase III study comparing the efficacy and safety of eribulin in 452 patients (aged 18 or over) to dacarbazine
The standard therapy arm consisted of four cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine
chemotherapy followed by radiation therapy at 30 Gy limited to the involved field.
AstraZeneca is also completing a Phase 2 trial with selumetinib in combination with dacarbazine
compared with dacarbazine
alone as first-line treatment of patients with melanoma whose tumors harbor BRAF mutations.