Expression of Cyclooxygenase-1
and Cydooxygenase-2 in human breast cancer.
An intriguing novel finding was that a dose-dependent increase in inhibition of platelet stickiness was seen in the diabetic patients even though their cyclooxygenase-1
activity was maximally inhibited at 81 mg/day.
Heterogeneity in the suppression of platelet cyclooxygenase-1
activity by aspirin in coronary heart disease.
Variants of cyclooxygenase-1
and their roles in medicine.
These effects are attributed to the drugs' inhibition of cyclooxygenase-1
(COX-1), which is found in the gastrointestinal tract.
EXPRESSION OF CYCLOOXYGENASE-1
AND -2 AND PROSTAGLANDIN E2 DURING POSTNATAL DEVELOPMENT OF RAT COLON.
The drawback, however, is that aspirin also inactivates cyclooxygenase-1
(COX-1), a related enzyme that produces prostaglandins, substances necessary for normal tissue function.
Metabolex scientists discovered that halofenate is an inhibitor of cyclooxygenase-1
(Cox-1), similar to common NSAIDs like Motrin(TM) or Naprosyn(TM), accounting for its GI side effects.
Vascular reactivity was assessed in mesenteric artery rings using organ chambers, oxidative stress by dihydroethidine staining and cyclooxygenase-1
(COX-1) and -2 (COX-2) expression by immunohistochemistry.
Because both aspirin and NSAIDs inhibit the action of the isoenzyme cyclooxygenase-1
(COX- 1), the researchers performed a subanalysis of the aspirin component of the study to examine the extent to which regular NSAID use blocked the benefits of aspirin.
The side effects of NSAIDs stem from their ability to block both cyclooxygenase-1
and -2 in the body.
Initially researchers hypothesized that the drugs combat Alzheimer's by inhibiting the secretion of cyclooxygenase-1
and -2 (COX-1 and COX-2) enzymes.
SAN FRANCISCO -- Licofelone,a novel NSAID that blocks cyclooxygenase-1
and -2 as well as 5-lipoxygenase, caused less gastric and duodenal injury than did naproxen in healthy volunteers and in osteoarthritis patients, said Dr.
Belonging to a class of medications called non-steroidal anti-inflammatory drugs, COX-2 inhibitors were developed in the late 1990s as an alternative to another group of medications called nonspecific NSAIDS, which inhibit the production of COX-2 along with the enzyme Cyclooxygenase-1
, or COX-1.
A single amino acid difference between cyclooxygenase-1
(COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors.