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  • noun

Synonyms for cyclooxygenase-1

an enzyme that regulates prostaglandins that are important for the health of the stomach lining and kidneys


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References in periodicals archive ?
Immunohistochemical determination of cyclooxygenase-1 and -2 expression in the mesenteric arterial wall
Cyclooxygenase-1 is involved in endothelial dysfunction of mesenteric small arteries from angiotensin II-infused mice.
Heterogeneity in the suppression of platelet cyclooxygenase-1 activity by aspirin in coronary heart disease.
The drawback, however, is that aspirin also inactivates cyclooxygenase-1 (COX-1), a related enzyme that produces prostaglandins, substances necessary for normal tissue function.
Metabolex scientists discovered that halofenate is an inhibitor of cyclooxygenase-1 (Cox-1), similar to common NSAIDs like Motrin(TM) or Naprosyn(TM), accounting for its GI side effects.
As can be seen in Figure 3, both cyclooxygenase-1 and cyclooxygenase-2 (COX-1 and COX-2) also participate in the degradation of arachidonic acid.
A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors.
The side effects of NSAIDs stem from their ability to block both cyclooxygenase-1 and -2 in the body.
SAN FRANCISCO -- Licofelone,a novel NSAID that blocks cyclooxygenase-1 and -2 as well as 5-lipoxygenase, caused less gastric and duodenal injury than did naproxen in healthy volunteers and in osteoarthritis patients, said Dr.
Belonging to a class of medications called non-steroidal anti-inflammatory drugs, COX-2 inhibitors were developed in the late 1990s as an alternative to another group of medications called nonspecific NSAIDS, which inhibit the production of COX-2 along with the enzyme Cyclooxygenase-1, or COX-1.
Brooks P, Emery P, Evans JF, Fenner H, Hawkey CJ, Patrono C, Smolen J, Bredveld F, Day R, Dougados M, Ehrich EW, Gijon-Banos J, Kvien TK, Van Rijswijk MH, Warner T, Zeidler H (1999) Interpreting the clinical significance of the differential inhibition of cyclooxygenase-1 and cyclooxygenase-2.
NSAIDs inhibit the synthesis of prostaglandins, notably cyclooxygenase-1 and cyclooxygenase-2, which are found in the brain.
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