The median change in CD4+ cell count from baseline was similar between the PREZISTA/r and lopinavir/r arms (137 cells per cubic millimeter
CD4 cell counts increased consistently over the 300-week period, with an average increase, from baseline, of 595 cells per cubic millimeter
observed for all patients remaining in the study.
The term means that a person has fewer than 300 T-lymphocytes per cubic millimeter
of blood and that this count cannot be explained by immunosuppressive drugs or other factors.
Among 38 MGDF patients, the researchers documented a median low platelet count of 188,000 per cubic millimeter
-- a 70 percent increase over the median low count of 111,000/cmm measured among the unexposed patients.
The agency also suggested that physicians use zalcitabine only for AIDS patients whose counts of CD4 cells, a key immune system component, have dropped below 300 per cubic millimeter
The NIH investigators reported that in a randomized, controlled study of 60 HIV infected patients, in 31 subjects mean CD4+ T-cell counts doubled from 428 cells at baseline to 916 cells per cubic millimeter
at 12 months.
The recruits also showed immune system damage by HIV: All had CD4-lymphocyte counts of between 200 and 500 cells per cubic millimeter
To be eligible for the study, a person must be HIV-infected and in reasonably good health, be 13 years of age or older and have a CD4+ T cell count between 50 and 350 cells per cubic millimeter
CD4 cell counts increased consistently over the five-year period, with an average increase of 510 cells per cubic millimeter
observed for all patients on treatment at 252 weeks.
Last fall, preliminary findings hinted that AIDS patients taking the drug zidovudine (AZT) have a better chance of prolonging their survival if their levels of certain immune cells, called CD4, stay above 50 cells per cubic millimeter
of blood (SN: 11/4/89, p.
Currently, HIV-infected children do not receive such treatment until their blood levels of CD4 T-lymphocytes fall below 500 per cubic millimeter
The eight people who developed B-cell lymphoma in his study had shown fewer than 50 CD4 T-lymphocytes per cubic millimeter
of blood for at least a year.