David Moskowitz, GenoMed's Chairman and CEO, said, "We believe our treatment will work in crush injury, just as it has worked for other causes of acute kidney failure.
Moskowitz continued, "Given that school-children are still trapped in the rubble, and at increasing risk for crush injury syndrome, it is reassuring to know that our treatment has already been used safely among the most vulnerable children: infants in a Neonatal ICU.
Actual results could differ materially from those projected in the forward looking statements as a result of a number of risks and uncertainties, including but not limited to: (a) whether patients with crush injury respond to this treatment approach, especially if they are rescued after a long time; (b) whether we will have sufficient financing to conduct our research and development; (c) how competition from existing or new competitors will impact our business, and (d) our research and development being subject to economic, regulatory, governmental, and technological factors.
In the present study, we investigated the effects of safranal on nerve function and histological changes following sciatic nerve crush injury.
Group 3: In this group intraperitoneal injection of paraffin was done for 10 consecutive days after surgically-induced crush injury in sciatic nerve and served as crush plus paraffin group.
8 mg/kg were performed after induction of a crush injury in sciatic nerve and served as safranal groups.
Group 7: In this group subcutaneous injection of rice bran oil was done for 10 consecutive days after surgically-induced crush injury in sciatic nerve and served as crush plus rice bran oil group.
The crush injury consisted of two 30 s crushes using fine forceps, each occurring at the same level of the nerve but with a 180[degrees] change in the orientation of the forceps around the nerve.
The negative electrode terminal was then sutured approximately 2 mm proximal to the crush injury site and the positive electrode terminal to connective tissue about 3 to 5 mm away from the negative terminal on the opposite side of the nerve, such that electrical current passing between the electrode terminals stimulated the regenerating axons in the nerve.
Our initial studies investigated the therapeutic potential of ES in nerve regeneration following a rat facial nerve crush injury because of ES's enhancing effects on the morphological and functional properties of neurons [1-4].
It has also been reported that, following sciatic nerve crush injury in rats, administering ES accelerates the appearance of the toe-spreading reflex, a sensitive indicator of the onset of motor recovery , further supporting the concept that ES enhances early regeneration events that initiate sprout formation.