Time Marker Late 1950s Aspartate aminotransferase (AST, SGOT) 1960s Creatine kinase
(CK, CPK (a)) 1970s Creatine kinase
isoenzyme (CK-MB activity) 1970s Lactate dehydrogenase isoenzymes (ratio of LD1 to LD2) Late 1980s CK-MB mass concentration Mid-1990s cTnI, cTnT (a) CPK, creatine phosphokinase; LD1, lactate dehydrogenase fraction 1; LD2, lactate dehydrogenase fraction 2.
Sensitive, rapid assay of subforms creatine kinase
MB in plasma.
The project consists of the purification of creatine kinase
isoenzyme CK-BB from human placenta.
9] Nonstandard abbreviations: ACS, acute coronary syndrome; CARMAGUE, Cardiac Marker Guideline Uptake in Europe study; cTn, cardiac troponin; CK, creatine kinase
; CK-MB, creatine kinase
Participants also had substantially elevated serum creatine kinase
levels due to the disease, and symptoms associated with DMD.
All clinical trial participants are boys with a nonsense mutation in the dystrophin gene, substantially elevated serum creatine kinase
levels, and symptoms associated with DMD.
A single such blood test identifies these patients, even when serial troponin T levels are undetectable and when creatine kinase
MB and C-reactive protein test results are equivocal.
We have been investigating the role of the creatine kinase
system in Central Nervous System Disorders for many years," said Rima Kaddurah-Daouk, Ph.
All patients were boys with a nonsense mutation in the dystrophin gene, substantially elevated serum creatine kinase
, and symptoms associated with DMD.
At that time, Creatine kinase
(adenosine triphosphate:creatine phophotransferase; EC 2.
Nadim Shaath of Alpha Research & Development presented work on the effects of the creatine kinase
system on the skin and also reviewed creatine's role in the production and regulation of cellular energy.
Some years ago, a project of the AACC subcommittee on creatine kinase
MB (CK-MB) mass assay standardization led to identification and characterization of a lyophilized CK-MB candidate reference material (in recombinant form) (6).
In a recent study, researchers estimated the prevalence of influenza-related myocarditis using measures of cardiac troponins and creatine kinase
, which are more specific markers of myocardial injury The study, involving 152 influenza patients at 60 U.
In contrast, creatine kinase
, myoglobin, alanine aminotransferase, [beta]-glutamyl transferase, lactate dehydrogenase, alkaline phosphatase, and the blood coagulation indicators were virtually inactivated, and free thyroxine was increased 2.
WASHINGTON -- Some patients who develop muscular pain while taking statins have severe muscle toxicity despite normal creatine kinase